Genome-scale metabolic modelling of human gut microbes to inform rational community design See

The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome therapeutically, its effectiveness is often limited by the microbial...

Predictive LES for jet aeroacoustics-current approach and industrial application See

The major techniques for measuring jet noise have significant drawbacks, especially when including engine installation effects such as jet-flap interaction noise. Numerical methods including low order correlations and Reynolds-Averaged Navier-Stokes (RANS) are known to be deficient for complex configuratio...

Promoting the Resolution of Thromboinflammation See

Background Thrombosis is viewed as a multi-step, multi-cellular process driven by inflammatory stimuli and leukocyte (e.g. neutrophil) activation, and is a major pathophysiological contributor of stroke. Accumulating data supports the hypothesis that anti-inflammatory therapies may limit thrombosis and&#x...

Developing a quality assessment tool for the Ghanaian construction industry See

Globally, there has been an increasing interest and demand in the adoption and implementation of quality management systems in the construction industry, as they provide heightened effectiveness and efficacy for client satisfaction. However, in Ghana, collapses of newly built and...

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions See

HIV-1 integration into host chromosomes, essential for viral replication, is catalysed by viral integrase (IN). IN recurrently targets intronic regions of transcriptionally active genes, but a detailed understanding of this process is still unclear. Here, using ex vivo activated human primary...

An empirical examination of lean production, agile production and supply chain collaboration on manufacturing sustainability in Saudi Arabia See

The contemporary constantly changing environment is a significant challenge that affects all organisations including manufacturing firms while implementing concepts underpinning a drive for sustainability, with government regulations, customer demands and supplier issues impacting these firms. Literatur...

Timeless: Wings ascend forever – novel extract and gothic reflections: The gothic double and double identities in timeless: Wings ascend forever and R. L. Stevenson’s the strange case of Dr Jekyll and Mr Hyde (1886), a... See

This thesis includes chapters one to nine of a novel and a critical reflective essay. My novel Timeless: Wings Ascend Forever is a neo-Victorian Gothic Fantasy inspired by R. L. Stevenson's The Strange Case of Dr Jekyll and Mr Hyde (1886). The novel examines th...

Numerical modelling and fire design of stainless steel hollow section columns See

In this paper, the elevated temperature buckling performance and design of cold-formed square, rectangular and circular hollow section columns made of stainless steel is studied through a numerical modelling investigation. The finite element analysis software Abaqus was employed to perform the&#x...

The effect of funding for disadvantaged students on academic underachievement See

We estimate the effect of school funding for disadvantaged students on academic underachievement in primary education. For this purpose, we exploit a policy in Belgium that granted additional funding for schools with a share of disadvantaged students of at least 10%. Combining stochasti...