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DC Field | Value | Language |
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dc.contributor.author | van der Valk, RJ | - |
dc.contributor.author | Kreiner-Møller, E | - |
dc.contributor.author | Kooijman, MN | - |
dc.contributor.author | Guxens, M | - |
dc.contributor.author | Stergiakouli, E | - |
dc.contributor.author | Sääf, A | - |
dc.contributor.author | Bradfield, JP | - |
dc.contributor.author | Geller, F | - |
dc.contributor.author | Hayes, MG | - |
dc.contributor.author | Cousminer, DL | - |
dc.contributor.author | Körner, A | - |
dc.contributor.author | Melbye, M | - |
dc.contributor.author | Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium | - |
dc.contributor.author | van Duijn, CM | - |
dc.contributor.author | Medina-Gomez, C | - |
dc.contributor.author | Hofman, A | - |
dc.contributor.author | de Jongste, JC | - |
dc.contributor.author | Taal, HR | - |
dc.contributor.author | Uitterlinden, AG | - |
dc.contributor.author | Genetic Investigation of ANthropometric Traits (GIANT) Consortium | - |
dc.contributor.author | Armstrong, LL | - |
dc.contributor.author | Murray, CS | - |
dc.contributor.author | Eriksson, J | - |
dc.contributor.author | Palotie, A | - |
dc.contributor.author | Bustamante, M | - |
dc.contributor.author | Estivill, X | - |
dc.contributor.author | Gonzalez, JR | - |
dc.contributor.author | Llop, S | - |
dc.contributor.author | Kiess, W | - |
dc.contributor.author | Mahajan, A | - |
dc.contributor.author | Flexeder, C | - |
dc.contributor.author | Tiesler, CM | - |
dc.contributor.author | Simpson, A | - |
dc.contributor.author | Magnus, P | - |
dc.contributor.author | Sengpiel, V | - |
dc.contributor.author | Hartikainen, AL | - |
dc.contributor.author | Keinanen-Kiukaanniemi, S | - |
dc.contributor.author | Lewin, A | - |
dc.contributor.author | Da Silva Couto Alves, A | - |
dc.contributor.author | Blakemore, AI | - |
dc.contributor.author | Buxton, JL | - |
dc.contributor.author | Lyytikäinen, LP | - |
dc.contributor.author | Kaakinen, M | - |
dc.contributor.author | Rodriguez, A | - |
dc.contributor.author | Sebert, S | - |
dc.contributor.author | Vaarasmaki, M | - |
dc.contributor.author | Lakka, T | - |
dc.contributor.author | Lindi, V | - |
dc.contributor.author | Gehring, U | - |
dc.contributor.author | Postma, DS | - |
dc.contributor.author | Ang, W | - |
dc.contributor.author | Newnham, JP | - |
dc.contributor.author | Pahkala, K | - |
dc.contributor.author | Raitakari, OT | - |
dc.contributor.author | Panoutsopoulou, K | - |
dc.contributor.author | Zeggini, E | - |
dc.contributor.author | Boomsma, DI | - |
dc.contributor.author | Groen-Blokhuis, M | - |
dc.contributor.author | Ilonen, J | - |
dc.contributor.author | Franke, L | - |
dc.contributor.author | Hirschhorn, JN | - |
dc.contributor.author | Lowe, WL | - |
dc.contributor.author | Pers, TH | - |
dc.contributor.author | Liang, L | - |
dc.contributor.author | Huang, J | - |
dc.contributor.author | Hocher, B | - |
dc.contributor.author | Knip, M | - |
dc.contributor.author | Saw, SM | - |
dc.contributor.author | Holloway, JW | - |
dc.contributor.author | Melén, E | - |
dc.contributor.author | Grant, SF | - |
dc.contributor.author | Feenstra, B | - |
dc.contributor.author | Widén, E | - |
dc.contributor.author | Sergeyev, E | - |
dc.contributor.author | Grallert, H | - |
dc.contributor.author | Custovic, A | - |
dc.contributor.author | Jacobsson, B | - |
dc.contributor.author | Jarvelin, MR | - |
dc.contributor.author | Atalay, M | - |
dc.contributor.author | Koppelman, GH | - |
dc.contributor.author | Pennell, CE | - |
dc.contributor.author | Thiering, E | - |
dc.contributor.author | Niinikoski, H | - |
dc.contributor.author | Dedoussis, GV | - |
dc.contributor.author | Mccarthy, MI | - |
dc.contributor.author | Frayling, TM | - |
dc.contributor.author | Sunyer, J | - |
dc.contributor.author | Timpson, NJ | - |
dc.contributor.author | Rivadeneira, F | - |
dc.contributor.author | Bønnelykke, K | - |
dc.contributor.author | Jaddoe, VW | - |
dc.contributor.author | Early Growth Genetics (EGG) Consortium | - |
dc.contributor.author | Curtin, JA | - |
dc.contributor.author | Myhre, R | - |
dc.contributor.author | Huikari, V | - |
dc.contributor.author | Joro, R | - |
dc.contributor.author | Kerkhof, M | - |
dc.contributor.author | Warrington, NM | - |
dc.contributor.author | Pitkänen, N | - |
dc.contributor.author | Ntalla, I | - |
dc.contributor.author | Horikoshi, M | - |
dc.contributor.author | Veijola, R | - |
dc.contributor.author | Freathy, RM | - |
dc.contributor.author | Teo, YY | - |
dc.contributor.author | Barton, SJ | - |
dc.contributor.author | Evans, DM | - |
dc.contributor.author | Kemp, JP | - |
dc.contributor.author | St Pourcain, B | - |
dc.contributor.author | Ring, SM | - |
dc.contributor.author | Davey Smith, G | - |
dc.contributor.author | Bergström, A | - |
dc.contributor.author | Kull, I | - |
dc.contributor.author | Hakonarson, H | - |
dc.contributor.author | Mentch, FD | - |
dc.contributor.author | Bisgaard, H | - |
dc.contributor.author | Chawes, B | - |
dc.contributor.author | Stokholm, J | - |
dc.contributor.author | Waage, J | - |
dc.contributor.author | Eriksen, P | - |
dc.contributor.author | Sevelsted, A | - |
dc.coverage.spatial | England | - |
dc.coverage.spatial | England | - |
dc.date.accessioned | 2015-07-24T10:27:28Z | - |
dc.date.available | 2015-02-15 | - |
dc.date.available | 2015-07-24T10:27:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Human Molecular Genetics, 24(4): 1155 - 1168, (2015) | en_US |
dc.identifier.issn | 1460-2083 | - |
dc.identifier.uri | http://hmg.oxfordjournals.org/content/24/4/1155 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/11179 | - |
dc.description.abstract | Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height. | en_US |
dc.description.sponsorship | R.M.F. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust grant 085541/Z/08/Z). T.H.P. is supported by The Danish Council for Independent Research Medical Sciences (FSS) The Alfred Benzon Foundation. B.F. is supported by an Oak Foundation fellowship. M.M. is a Wellcome Trust Senior Investigator (Wellcome Trust grant 090532) and a NIHR Senior Investigator. T.M.F. is supported by the European Research Council grant: SZ-245 50371- GLUCOSEGENES-FP7-IDEAS-ERC. F.R. (VIDI 016.136.367) and V.W.V.J. (VIDI 016.136.361) received grants from the Netherlands Organization for Health Research and Development. | en_US |
dc.format.extent | 1155 - 1168 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | Genetic variants | en_US |
dc.subject | Skeletal growth | en_US |
dc.subject | Single nucleotide polymorphisms (SNPs) | en_US |
dc.subject | Adult height | en_US |
dc.subject | DCST2 | en_US |
dc.subject | Early growth | en_US |
dc.title | A novel common variant in DCST2 is associated with length in early life and height in adulthood. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1093/hmg/ddu510 | - |
dc.relation.isPartOf | Hum Mol Genet | - |
pubs.issue | 4 | - |
pubs.volume | 24 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
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