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DC Field | Value | Language |
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dc.contributor.author | de Castro, IJ | - |
dc.contributor.author | Budzak, J | - |
dc.contributor.author | Di Giacinto, ML | - |
dc.contributor.author | Ligammari, L | - |
dc.contributor.author | Gokhan, E | - |
dc.contributor.author | Spanos, C | - |
dc.contributor.author | Moralli, D | - |
dc.contributor.author | Richardson, C | - |
dc.contributor.author | de las Heras, J | - |
dc.contributor.author | Salatino, S | - |
dc.contributor.author | Shirmer, E | - |
dc.contributor.author | Ullman, K | - |
dc.contributor.author | Bickmore, W | - |
dc.contributor.author | Rappsilber, J | - |
dc.contributor.author | Lamble, S | - |
dc.contributor.author | Golberg, M | - |
dc.contributor.author | Vinciotti, V | - |
dc.contributor.author | Vagnarelli, P | - |
dc.date.accessioned | 2016-11-25T15:52:04Z | - |
dc.date.available | 2016-11-25T15:52:04Z | - |
dc.date.issued | 2017-01-16 | - |
dc.identifier.citation | de Castro, I., Budzak, J., Di Giacinto, M. et al. Repo-Man/PP1 regulates heterochromatin formation in interphase. Nat Commun 8, 14048 | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/13546 | - |
dc.description.abstract | Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with chromatin but its function in interphase is not known. Here we show that Repo-Man, via Nup153, is enriched on condensed chromatin at the nuclear periphery and at the edge of the nucleopore basket. Repo-Man/PP1 regulates the formation of heterochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 binding and H3K27me3 recruitment. Using a novel proteogenomic approach, we show that Repo-Man is enriched at subtelomeric regions together with H2AZ and H3.3 and that depletion of Repo-Man alters the peripheral localization of a subset of these regions and alleviates repression of some polycomb telomeric genes. This study shows a role for a mitotic phosphatase in the regulation of the epigenetic landscape and gene expression in interphase. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | Cell division | - |
dc.subject | Chromatin | - |
dc.subject | Epigenetics | - |
dc.title | Repo-Man/PP1 regulates heterochromatin formation in interphase | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1038/ncomms14048 | - |
dc.relation.isPartOf | Nature Communications | - |
pubs.publication-status | Published | - |
dc.identifier.eissn | 2041-1723 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
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