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http://bura.brunel.ac.uk/handle/2438/15384
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DC Field | Value | Language |
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dc.contributor.author | Yang, Q | - |
dc.contributor.author | Bright, C | - |
dc.contributor.author | Edwards, NA | - |
dc.contributor.author | Harris, GH | - |
dc.contributor.author | Kaur, S | - |
dc.contributor.author | Wood, PL | - |
dc.contributor.author | Hewitson, P | - |
dc.contributor.author | Ignatova, S | - |
dc.date.accessioned | 2017-11-07T13:37:17Z | - |
dc.date.available | 2017-10-20 | - |
dc.date.available | 2017-11-07T13:37:17Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Organic Process Research and Development, 2017, 21 (10), pp. 1638 - 1643 | en_US |
dc.identifier.issn | 1083-6160 | - |
dc.identifier.issn | 1520-586X | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/15384 | - |
dc.description.abstract | © 2017 American Chemical Society. A high-performance countercurrent chromatography (HPCCC) process was developed as a more efficient and sustainable alternative to reverse phase high-performance liquid chromatography (RP-HPLC) for the pilot-scale purification of the naturally occurring fermentation-derived insecticides, spinosyn A and spinosyn D, the major components of spinosad insecticide. While on pilot scale HPCCC and RP-HPLC both gave > 99% purities and comparable combined recoveries of 77% and 83%, respectively, HPCCC was much more efficient and sustainable by producing a 60% higher productivity, 11 times higher solute loading, 96% savings in stationary phase costs, and 42% reduction in solvent usage. The increase in productivity and reduction in solvent usage further reduced waste recycle and disposal costs, thus presenting significantly less environmental impact compared to RP-HPLC separations. The use of mixing on demand for a solvent system at the preparative scale allowed a complete automation with minimized solvent consumption. | en_US |
dc.format.extent | 1638 - 1643 | - |
dc.language.iso | en | en_US |
dc.title | Development of a Scalable and Sustainable High Performance CounterCurrent Chromatography (HPCCC) Purification for Spinosyn A and Spinosyn D from Spinosad | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1021/acs.oprd.7b00249 | - |
dc.relation.isPartOf | Organic Process Research and Development | - |
pubs.issue | 10 | - |
pubs.publication-status | Published | - |
pubs.volume | 21 | - |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Embargoed Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Fulltext.pdf | Embargoed until 12 months after publication | 2.21 MB | Adobe PDF | View/Open |
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