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dc.contributor.authorYang, Q-
dc.contributor.authorBright, C-
dc.contributor.authorEdwards, NA-
dc.contributor.authorHarris, GH-
dc.contributor.authorKaur, S-
dc.contributor.authorWood, PL-
dc.contributor.authorHewitson, P-
dc.contributor.authorIgnatova, S-
dc.identifier.citationOrganic Process Research and Development, 2017, 21 (10), pp. 1638 - 1643en_US
dc.description.abstract© 2017 American Chemical Society. A high-performance countercurrent chromatography (HPCCC) process was developed as a more efficient and sustainable alternative to reverse phase high-performance liquid chromatography (RP-HPLC) for the pilot-scale purification of the naturally occurring fermentation-derived insecticides, spinosyn A and spinosyn D, the major components of spinosad insecticide. While on pilot scale HPCCC and RP-HPLC both gave > 99% purities and comparable combined recoveries of 77% and 83%, respectively, HPCCC was much more efficient and sustainable by producing a 60% higher productivity, 11 times higher solute loading, 96% savings in stationary phase costs, and 42% reduction in solvent usage. The increase in productivity and reduction in solvent usage further reduced waste recycle and disposal costs, thus presenting significantly less environmental impact compared to RP-HPLC separations. The use of mixing on demand for a solvent system at the preparative scale allowed a complete automation with minimized solvent consumption.en_US
dc.format.extent1638 - 1643-
dc.titleDevelopment of a Scalable and Sustainable High Performance CounterCurrent Chromatography (HPCCC) Purification for Spinosyn A and Spinosyn D from Spinosaden_US
dc.relation.isPartOfOrganic Process Research and Development-
Appears in Collections:Dept of Mechanical Aerospace and Civil Engineering Embargoed Research Papers

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