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dc.contributor.advisorHickson, SS-
dc.contributor.authorLi, Y-
dc.contributor.authorHickson, SS-
dc.contributor.authorMcEniery, CM-
dc.contributor.authorWilkinson, IB-
dc.identifier.citationJournal of Li, Y., Hickson, S.S., McEniery, C.M., Wilkinson, I.B.; and Khir, A.W. (2019) 'Stiffening and ventricular–arterial interaction in the ascending aorta using MRI', Journal of Hypertension, 37(2) pp. 347-355 doi: 10.1097/HJH.0000000000001886.en_US
dc.description.abstract2018 The Author(s). Objectives: The aim of this study was to investigate the effect of age and sex on nPWV and ndI in the ascending aorta of healthy humans. Background: Local pulse wave velocity (nPWV) and wave intensity (ndI) in the human ascending aorta have not been studied adequately, due to the need for invasive pressure measurements. However, a recently developed technique made the non-invasive determination of nPWV and ndI possible using measurements of flow velocity and arterial diameter. Methods: Diameter and flow velocity were measured at the level of the ascending aorta in 144 healthy subjects (aged 20-77 years, 66 male), using magnetic resonance imaging. nPWV, ndI parameters; forward (FCW); backward (BCW) compression waves, forward decompression wave (FDW), local aortic distensibility (nDs) and reflection index (nRI) were calculated. Results: nPWV increased significantly with age from 4.7±0.3 m/s for those 20-30 years to 6.4±0.2 m/s for those 70-80 years (P<0.001) and did not differ between sexes. nDs decreased with age (5.3±0.5 vs. 2.6±0.2 10-5 1/Pa, P<0.001) and nRI increased with age (0.17±0.03 vs. 0.39±0.06, P<0.01) for those 20-30 and 70-80 years, respectively. FCW, BCW and FDW decreased significantly with age by 86.3%, 71.3% and 74.2%, respectively (P<0.001), all compared to the lowest age-band. Conclusions: In healthy humans, ageing results in stiffer ascending aorta, with increase in nPWV and decrease in nDs. A decrease in FCW and FDW indicates decline in left ventricular early and late systolic functions with age in healthy humans with no differences between sexes. nRI is more sensitive than BCW in establishing the effects of ageing on reflected waves measured in the ascending aorta.en_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.rightsPublished by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.-
dc.subjectpulse wave velocityen_US
dc.subjectwave intensity analysisen_US
dc.subjectlocal arterial propertiesen_US
dc.titleStiffening and ventricular-arterial interaction in the ascending aorta using Magnetic Resonance Imaging: Ageing effects in healthy humansen_US
dc.relation.isPartOfJournal of Hypertension-
Appears in Collections:Dept of Mechanical and Aerospace Engineering Research Papers

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