Please use this identifier to cite or link to this item:
Title: Multi-scale interaction of particulate flow and the artery wall
Authors: Halliday, I
Atherton, M
Care, CM
Collins, MW
Evans, D
Evans, PC
Hose, DR
Khir, AW
König, CS
Krams, R
Lawford, PV
Lishchuk, SV
Pontrelli, G
Ridger, V
Spencer, TJ
Ventikos, Y
Walker, DC
Watton, PN
Keywords: Multi-scale;Microcirculation;Endothelium;Wall shear stress;Glycocalyx
Issue Date: 2011
Publisher: Elsevier
Citation: Medical Engineering & Physics, 2010, Forthcoming
Abstract: We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.
ISSN: S1350-4533(10)00203-1
Other Identifiers: S1350-4533(10)00203-1
Appears in Collections:Mechanical and Aerospace Engineering
Dept of Mechanical and Aerospace Engineering Research Papers

Files in This Item:
File Description SizeFormat 
Fulltext.pdf1.6 MBAdobe PDFView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.