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DC Field | Value | Language |
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dc.contributor.author | Wu, L | - |
dc.contributor.author | Virdee, J | - |
dc.contributor.author | Maughan, E | - |
dc.contributor.author | Darbyshire, A | - |
dc.contributor.author | Jell, G | - |
dc.contributor.author | Loizidou, M | - |
dc.contributor.author | Emberton, M | - |
dc.contributor.author | Butler, P | - |
dc.contributor.author | Howkins, A | - |
dc.contributor.author | Reynolds, A | - |
dc.contributor.author | Boyd, IW | - |
dc.contributor.author | Birchall, M | - |
dc.contributor.author | Song, W | - |
dc.date.accessioned | 2018-12-12T10:44:40Z | - |
dc.date.available | 2018-10-15 | - |
dc.date.available | 2018-12-12T10:44:40Z | - |
dc.date.issued | 2018-10-15 | - |
dc.identifier.citation | Wu, L., Virdee, J., Maughan, E., Darbyshire, A., Jell, G., Loizidou, M., Emberton, M., Butler, P., Howkins, A., Reynolds, A., Boyd, I.W., Birchall, M. and Song, W. (2018) 'Stiffness memory nanohybrid scaffolds generated by indirect 3D printing for biologically responsive soft implants', Acta Biomaterialia, 80, pp. 188-202. doi: https://doi.org/10.1016/j.actbio.2018.09.016. | en_US |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/17211 | - |
dc.description.abstract | © 2018 The Authors. Cell and tissue stiffness is an important biomechanical signalling parameter for dynamic biological pro-cesses; responsive polymeric materials conferring responsive functionality are therefore appealing forin vivoimplants. We have developed thermoresponsive poly(urea-urethane) nanohybrid scaffolds with‘stiffness memory’ through a versatile 3D printing-guided thermally induced phase separation (3D-TIPS) technique. 3D-TIPS, a combination of 3D printing with phase separation, allows uniform phase-separation and phase transition of the polymer solution at a large interface of network within the printedsacrificial preform, leading to the creation of full-scale scaffolds with bespoke anatomical complex geom-etry. A wide range of hyperelastic mechanical properties of the soft elastomer scaffolds with intercon-nected pores at multi-scale, controlled porosity and crystallinity have been manufactured, notpreviously achievable via direct printing techniques or phase-separation alone. Semi-crystalline poly-meric reverse self-assembly to a ground-stated quasi-random nanophase structure, throughout a hierar-chical structure of internal pores, contributes to gradual stiffness relaxation duringin vitrocell culturewith minimal changes to shape. This ‘stiffness memory’ provides initial mechanical support to surround-ing tissues before gradually softening to a better mechanical match, raising hopes for personalized andbiologically responsive soft tissue implants which promote human fibroblast cells growth as modeland potential scaffold tissue integration. | en_US |
dc.description.sponsorship | UK Engineering and Physical Sciences Research Council (EPSRC EP/L020904/1, EP/M026884/1 and EP/R02961X/1). | en_US |
dc.format.extent | 188 - 202 | - |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd. on behalf of Acta Materialia Inc. | en_US |
dc.rights | This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | stiffness memory | en_US |
dc.subject | 3D-TIPS | en_US |
dc.subject | 3D printing | en_US |
dc.subject | phase separation | en_US |
dc.subject | polyurethane nanohybrid | en_US |
dc.subject | soft implants | en_US |
dc.title | Stiffness memory nanohybrid scaffolds generated by indirect 3D printing for biologically responsive soft implants | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.actbio.2018.09.016 | - |
dc.relation.isPartOf | Acta Biomaterialia | - |
pubs.publication-status | Published | - |
pubs.volume | 80 | - |
dc.identifier.eissn | 1878-7568 | - |
Appears in Collections: | The Experimental Techniques Centre |
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