Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/17211
Title: | Stiffness memory nanohybrid scaffolds generated by indirect 3D printing for biologically responsive soft implants |
Authors: | Wu, L Virdee, J Maughan, E Darbyshire, A Jell, G Loizidou, M Emberton, M Butler, P Howkins, A Reynolds, A Boyd, IW Birchall, M Song, W |
Keywords: | stiffness memory;3D-TIPS;3D printing;phase separation;polyurethane nanohybrid;soft implants |
Issue Date: | 15-Oct-2018 |
Publisher: | Elsevier Ltd. on behalf of Acta Materialia Inc. |
Citation: | Wu, L., Virdee, J., Maughan, E., Darbyshire, A., Jell, G., Loizidou, M., Emberton, M., Butler, P., Howkins, A., Reynolds, A., Boyd, I.W., Birchall, M. and Song, W. (2018) 'Stiffness memory nanohybrid scaffolds generated by indirect 3D printing for biologically responsive soft implants', Acta Biomaterialia, 80, pp. 188-202. doi: https://doi.org/10.1016/j.actbio.2018.09.016. |
Abstract: | © 2018 The Authors. Cell and tissue stiffness is an important biomechanical signalling parameter for dynamic biological pro-cesses; responsive polymeric materials conferring responsive functionality are therefore appealing forin vivoimplants. We have developed thermoresponsive poly(urea-urethane) nanohybrid scaffolds with‘stiffness memory’ through a versatile 3D printing-guided thermally induced phase separation (3D-TIPS) technique. 3D-TIPS, a combination of 3D printing with phase separation, allows uniform phase-separation and phase transition of the polymer solution at a large interface of network within the printedsacrificial preform, leading to the creation of full-scale scaffolds with bespoke anatomical complex geom-etry. A wide range of hyperelastic mechanical properties of the soft elastomer scaffolds with intercon-nected pores at multi-scale, controlled porosity and crystallinity have been manufactured, notpreviously achievable via direct printing techniques or phase-separation alone. Semi-crystalline poly-meric reverse self-assembly to a ground-stated quasi-random nanophase structure, throughout a hierar-chical structure of internal pores, contributes to gradual stiffness relaxation duringin vitrocell culturewith minimal changes to shape. This ‘stiffness memory’ provides initial mechanical support to surround-ing tissues before gradually softening to a better mechanical match, raising hopes for personalized andbiologically responsive soft tissue implants which promote human fibroblast cells growth as modeland potential scaffold tissue integration. |
URI: | https://bura.brunel.ac.uk/handle/2438/17211 |
DOI: | https://doi.org/10.1016/j.actbio.2018.09.016 |
ISSN: | 1742-7061 |
Appears in Collections: | The Experimental Techniques Centre |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 7.5 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License