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DC Field | Value | Language |
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dc.contributor.author | Hasso-Agopsowicz, M | - |
dc.contributor.author | Scriba, TJ | - |
dc.contributor.author | Hanekom, WA | - |
dc.contributor.author | Dockrell, HM | - |
dc.contributor.author | Smith, SG | - |
dc.date.accessioned | 2020-01-29T15:20:20Z | - |
dc.date.available | 2018-12-01 | - |
dc.date.available | 2020-01-29T15:20:20Z | - |
dc.date.issued | 2018-08-30 | - |
dc.identifier.citation | Scientific Reports, 2018, 8 (1) | en_US |
dc.identifier.issn | http://dx.doi.org/10.1038/s41598-018-31537-9 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/20139 | - |
dc.description.abstract | © 2018, The Author(s). Bacillus Calmette–Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA methylation in peripheral blood mononuclear cells (PBMC) from BCG vaccinated infants was measured and comparisons made between low and high BCG-specific cytokine responders. We found 318 genes and 67 pathways with distinct patterns of DNA methylation, including immune pathways, e.g. for T cell activation, that are known to directly affect immune responses. We also highlight signalling pathways that could indirectly affect the BCG-induced immune response: potassium and calcium channel, muscarinic acetylcholine receptor, G Protein coupled receptor (GPCR), glutamate signalling and WNT pathways. This study suggests that in addition to immune pathways, cellular processes drive vaccine-induced immune responses. Our results highlight mechanisms that require consideration when designing new TB vaccines. | en_US |
dc.description.sponsorship | European Commission within Horizon2020 TBVAC2020 (Grant No. H2020 PHC-643381); National Institutes of Health grant RO1-AI065653, European and Developing Countries Clinical Trial Partnership, Aeras, and the Bill and Melinda Gates Foundation through Grand Challenges in Global Health grant 37772 (“Biomarkers of Protective Immunity against TB in the context of HIV/AIDS in Africa”). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Research | en_US |
dc.title | Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1038/s41598-018-31537-9 | - |
dc.relation.isPartOf | Scientific Reports | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 8 | - |
dc.identifier.eissn | 2045-2322 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
Files in This Item:
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FullText.pdf | 3.44 MB | Adobe PDF | View/Open |
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