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Title: Simulation study on the formation of plga micro-structure using hot-pressing method
Authors: Gao, Y
Xu, C
Yang, L
Wang, B
Keywords: Visco-elastic property;PLGA Micro-structure;Hot-pressing method;Process parameters
Issue Date: 1-Dec-2019
Publisher: DAAAM Int.
Citation: International Journal of Simulation Modelling, 2019, 18 (4), pp. 643 - 653
Abstract: © 2019, DAAAM International Vienna. All rights reserved. A novel controlled drug delivery system was proposed, which contains a micro-structure for drug loading fabricated by using Poly(lactic-co-glycolic acid) (PLGA) via the hot-pressing method. The integrity of the PLGA micro-structure is the basis of the drug release control, but the visco-elastic property of PLGA causes the incomplete formation in the hot-pressing process. To obtain the improved hot-pressing parameters, the hot-pressing model of PLGA materials was established by using a 5-unit generalized Maxwell model. The influence of different hot-pressing parameters on the forming quality was studied. Simulation results show that the PLGA micro-structure was completely formed at the temperature of 75 °C, 1 mm base thickness, 30 N pressure, and 150 s maintenance time. The simulation results were validated by the hot-pressing fabrication. This study could lead theoretical basis for the preparation of visco-elastic polymer micro-structure by using the hot-pressing method and lay a foundation for the further optimization of hot-pressing process parameters.
ISSN: 1726-4529
Appears in Collections:Dept of Mechanical Aerospace and Civil Engineering Research Papers

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