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DC Field | Value | Language |
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dc.contributor.author | Giudici, A | - |
dc.contributor.author | Khir, AW | - |
dc.contributor.author | Szafron, JM | - |
dc.contributor.author | Spronck, B | - |
dc.date.accessioned | 2021-07-20T09:56:27Z | - |
dc.date.available | 2021-07-20T09:56:27Z | - |
dc.date.issued | 2021-06-03 | - |
dc.identifier.citation | Giudici, A., Khir, A.W., Szafron, J.M. and Spronck, B. (2021) 'From Uniaxial Testing of Isolated Layers to a Tri-Layered Arterial Wall: A Novel Constitutive Modelling Framework', Annals of Biomedical Engineering, 49, pp. 2454-2467. doi: 10.1007/s10439-021-02775-2. | en_US |
dc.identifier.issn | 0090-6964 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/22970 | - |
dc.description.abstract | Mechanical testing and constitutive modelling of isolated arterial layers yields insight into the individual layers’ mechanical properties, but per se fails to recapitulate the in vivo loading state, neglecting layer-specific residual stresses. The aim of this study was to develop a testing/modelling framework that integrates layer-specific uniaxial testing data into a three-layered model of the arterial wall, thereby enabling study of layer-specific mechanics under realistic (patho)physiological conditions. Circumferentially and axially oriented strips of pig thoracic aortas (n = 10) were tested uniaxially. Individual arterial layers were then isolated from the wall, tested, and their mechanical behaviour modelled using a hyperelastic strain energy function. Subsequently, the three layers were computationally assembled into a single flat-walled sample, deformed into a cylindrical vessel, and subjected to physiological tension-inflation. At the in vivo axial stretch of 1.10 ± 0.03, average circumferential wall stress was 75 ± 9 kPa at 100 mmHg, which almost doubled to 138 ± 15 kPa at 160 mmHg. A ~ 200% stiffening of the adventitia over the 60 mmHg pressure increase shifted layer-specific load-bearing from the media (65 ± 10% → 61 ± 14%) to the adventitia (28 ± 9% → 32 ± 14%). Our approach provides valuable insight into the (patho)physiological mechanical roles of individual arterial layers at different loading states, and can be implemented conveniently using simple, inexpensive and widely available uniaxial testing equipment. | en_US |
dc.description.abstract | Copyright © 2021 The Author(s). Mechanical testing and constitutive modelling of isolated arterial layers yields insight into the individual layers’ mechanical properties, but per se fails to recapitulate the in vivo loading state, neglecting layer-specific residual stresses. The aim of this study was to develop a testing/modelling framework that integrates layer-specific uniaxial testing data into a three-layered model of the arterial wall, thereby enabling study of layer-specific mechanics under realistic (patho)physiological conditions. Circumferentially and axially oriented strips of pig thoracic aortas (n = 10) were tested uniaxially. Individual arterial layers were then isolated from the wall, tested, and their mechanical behaviour modelled using a hyperelastic strain energy function. Subsequently, the three layers were computationally assembled into a single flat-walled sample, deformed into a cylindrical vessel, and subjected to physiological tension-inflation. At the in vivo axial stretch of 1.10 ± 0.03, average circumferential wall stress was 75 ± 9 kPa at 100 mmHg, which almost doubled to 138 ± 15 kPa at 160 mmHg. A ~ 200% stiffening of the adventitia over the 60 mmHg pressure increase shifted layer-specific load-bearing from the media (65 ± 10% → 61 ± 14%) to the adventitia (28 ± 9% → 32 ± 14%). Our approach provides valuable insight into the (patho)physiological mechanical roles of individual arterial layers at different loading states, and can be implemented conveniently using simple, inexpensive and widely available uniaxial testing equipment. | - |
dc.description.sponsorship | ARTERY (Association for Research into Arterial Structure and Physiology) society (2019 Research Exchange Grant to A.G.); European Union’s Horizon 2020 Research and Innovation program (Grant 793805 to B.S.). | en_US |
dc.format.extent | 2454 - 2467 | - |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature on behalf of the Biomedical Engineering Society | en_US |
dc.rights | Copyright © 2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | - |
dc.subject | tri-layered arterial wall model | en_US |
dc.subject | residual stresses | en_US |
dc.subject | layer-specific mechanics | en_US |
dc.subject | aorta | en_US |
dc.subject | arterial mechanics | en_US |
dc.title | From Uniaxial Testing of Isolated Layers to a Tri-Layered Arterial Wall: A Novel Constitutive Modelling Framework | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1007/s10439-021-02775-2 | - |
dc.relation.isPartOf | Annals of Biomedical Engineering | - |
pubs.publication-status | Published | - |
pubs.volume | 49 | - |
dc.identifier.eissn | 1573-9686 | - |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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