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http://bura.brunel.ac.uk/handle/2438/23036
Title: | Regulatory light chains in cardiac development and disease |
Authors: | Markandran, K Poh, JW Ferenczi, MA Cheung, C |
Keywords: | regulatory light chains;myosin regulatory light chain 2;RLC phosphorylation;cardiogenesis;cardiac muscle contractility |
Issue Date: | 21-Apr-2021 |
Publisher: | MDPI AG |
Citation: | Markandran, K., Poh, J.W., Ferenczi, M.A. and Cheung, C. (2021) ‘Regulatory Light Chains in Cardiac Development and Disease’, International Journal of Molecular Sciences, 22(9), 4351, p. 1-14. doi: 10.3390/ijms22094351. |
Abstract: | Copyright © 2021 The Author(s). The role of regulatory light chains (RLCs) in cardiac muscle function has been elucidated progressively over the past decade. The RLCs are among the earliest expressed markers during car-diogenesis and persist through adulthood. Failing hearts have shown reduced RLC phosphoryla-tion levels and that restoring baseline levels of RLC phosphorylation is necessary for generating optimal force of muscle contraction. The signalling mechanisms triggering changes in RLC phos-phorylation levels during disease progression remain elusive. Uncovering this information may provide insights for better management of heart failure patients. Given the cardiac chamber-specific expression of RLC isoforms, ventricular RLCs have facilitated the identification of mature ventricular cardiomyocytes, opening up possibilities of regenerative medicine. This review consolidates the standing of RLCs in cardiac development and disease and highlights knowledge gaps and potential therapeutic advancements in targeting RLCs. |
URI: | https://bura.brunel.ac.uk/handle/2438/23036 |
DOI: | https://doi.org/10.3390/ijms22094351 |
ISSN: | 1661-6596 |
Other Identifiers: | 4351 |
Appears in Collections: | Brunel Library |
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