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DC Field | Value | Language |
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dc.contributor.author | Charani, E | - |
dc.contributor.author | McKee, M | - |
dc.contributor.author | Ahmad, R | - |
dc.contributor.author | Balasegaram, M | - |
dc.contributor.author | Bonaconsa, C | - |
dc.contributor.author | Merrett, GB | - |
dc.contributor.author | Busse, R | - |
dc.contributor.author | Carter, V | - |
dc.contributor.author | Castro-Sanchez, E | - |
dc.contributor.author | Franklin, BD | - |
dc.contributor.author | Georgiou, P | - |
dc.contributor.author | Hill-Cawthorne, K | - |
dc.contributor.author | Hope, W | - |
dc.contributor.author | Imanaka, Y | - |
dc.contributor.author | Kambugu, A | - |
dc.contributor.author | Leather, AJ | - |
dc.contributor.author | Mbamalu, O | - |
dc.contributor.author | McLeod, M | - |
dc.contributor.author | Mendelson, M | - |
dc.contributor.author | Mpundu, M | - |
dc.contributor.author | Rawson, TM | - |
dc.contributor.author | Ricciardi, W | - |
dc.contributor.author | Rodriguez-Manzano, J | - |
dc.contributor.author | Singh, S | - |
dc.contributor.author | Tsioutis, C | - |
dc.contributor.author | Uchea, C | - |
dc.contributor.author | Zhu, N | - |
dc.contributor.author | Holmes, AH | - |
dc.date.accessioned | 2023-01-13T18:15:03Z | - |
dc.date.available | 2023-01-13T18:15:03Z | - |
dc.date.issued | 2021-06-29 | - |
dc.identifier | ORCID iDs: Enrique Castro-Sánchez https://orcid.org/0000-0002-3351-9496; Alison H Holmes https://orcid.org/0000-0001-5554-5743. | - |
dc.identifier | 100161 | - |
dc.identifier.citation | Charani, E. et al. (2021) 'Optimising antimicrobial use in humans – review of current evidence and an interdisciplinary consensus on key priorities for research', The Lancet Regional Health - Europe, 7, 100161, pp. 1 - 10. doi: 10.1016/j.lanepe.2021.100161. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25775 | - |
dc.description | Data sharing: The data used to inform this policy paper can be made able, upon reasonable request from Esmita Charani, e.charani@imperial.ac.uk. | en_US |
dc.description.abstract | Copyright © 2021 The Author(s). Addressing the silent pandemic of antimicrobial resistance (AMR) is a focus of the 2021 G7 meeting. A major driver of AMR and poor clinical outcomes is suboptimal antimicrobial use. Current research in AMR is inequitably focused on new drug development. To achieve antimicrobial security we need to balance AMR research efforts between development of new agents and strategies to preserve the efficacy and maximise effectiveness of existing agents. Combining a review of current evidence and multistage engagement with diverse international stakeholders (including those in healthcare, public health, research, patient advocacy and policy) we identified research priorities for optimising antimicrobial use in humans across four broad themes: policy and strategic planning; medicines management and prescribing systems; technology to optimise prescribing; and context, culture and behaviours. Sustainable progress depends on: developing economic and contextually appropriate interventions; facilitating better use of data and prescribing systems across healthcare settings; supporting appropriate and scalable technological innovation. Implementing this strategy for AMR research on the optimisation of antimicrobial use in humans could contribute to equitable global health security. | en_US |
dc.description.sponsorship | Wellcome Trust; Economic and Social Research Council (ESRC); National Institute for Health Research ASPIRES project (Antibiotic use across Surgical Pathways: Investigating, Redesigning and Evaluating Systems) (https://www.imperial.ac.uk/arc/aspires/); National Institute for Health Research, UK Department of Health [HPRU-2012-10047] in partnership with Public Health England. | en_US |
dc.format.extent | 1 - 10 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2021 The Author(s). Published by Elsevier Ltd. under a Creative Commons license(https://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.title | Optimising antimicrobial use in humans – review of current evidence and an interdisciplinary consensus on key priorities for research | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.lanepe.2021.100161 | - |
dc.relation.isPartOf | The Lancet Regional Health - Europe | - |
pubs.publication-status | Published | - |
pubs.volume | 7 | - |
dc.identifier.eissn | 2666-7762 | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Arts and Humanities Research Papers |
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File | Description | Size | Format | |
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FullText.pdf | Copyright © 2021 The Author(s). Published by Elsevier Ltd. under a Creative Commons license(https://creativecommons.org/licenses/by-nc-nd/4.0/). | 2.01 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License