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Title: Occupational and environmental exposures and myelodysplasia: A case-control study
Authors: West, RR
Stafford, DA
Farrow, A
Jacobs, A
Keywords: Myelodysplasia;Case-control study;Exposure;Occupation;Environment;Chemicals;Radiation
Issue Date: 1995
Publisher: Pergamon Press
Citation: Leukemia Research. 19(2): 127-139
Abstract: A case-control study of newly diagnosed myelodysplastic syndrome patients investigated lifetime exposures through occupation, environment or hobby by questionnaire, structured and semi-structured interview. The exposure histories of 400 individually matched pairs were compared. Increased or possibly increased odds ratios were observed for radiation (2.05, 95% confidence interval 1.16–3.76), halogenated organics (1.57, 0.97–2.57), metals (1.40, 0.99–2.00), several specific radiation exposures and individual chemicals and for childlessness (1.46, 1.01–2.11). Since myelodysplasia generally carries a poor prognosis, whether or not individuals convert to leukaemia or to other cancer, these findings add to previous reports of exposures implicated in the aetiology of leukaemia and add to the case for minimizing exposures to radiation and halogenated organics.
ISSN: 0145-2126
Appears in Collections:Community Health and Public Health
Dept of Clinical Sciences Research Papers

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