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DC Field | Value | Language |
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dc.contributor.author | Mann, A | - |
dc.contributor.author | Strange, RC | - |
dc.contributor.author | König, CS | - |
dc.contributor.author | Hackett, G | - |
dc.contributor.author | Haider, A | - |
dc.contributor.author | Haider, KS | - |
dc.contributor.author | Desnerck, P | - |
dc.contributor.author | Ramachandran, S | - |
dc.date.accessioned | 2024-02-04T18:19:44Z | - |
dc.date.available | 2024-02-04T18:19:44Z | - |
dc.date.issued | 2023-12-26 | - |
dc.identifier | ORCID iD: Amar Mann https://orcid.org/0000-0002-7972-4794 | - |
dc.identifier | ORCID iD: Richard C Strange https://orcid.org/0000-0002-0980-6348 | - |
dc.identifier | ORCID iD: Carola S König https://orcid.org/0000-0002-9289-3154 | - |
dc.identifier | ORCID iD: Geoffrey Hackett https://orcid.org/0000-0003-2073-3001 | - |
dc.identifier | ORCID iD: Ahmad Haider https://orcid.org/0000-0001-9252-0588 | - |
dc.identifier | ORCID iD: Karim Sultan Haider https://orcid.org/0000-0003-4396-9324 | - |
dc.identifier | ORCID iD: Peter Desnerck https://orcid.org/0000-0002-8042-9741 | - |
dc.identifier | ORCID iD: Sudarshan Ramachandran https://orcid.org/0000-0003-2299-4133 | - |
dc.identifier.citation | Mann, A. et al. (2023) 'Testosterone replacement therapy: association with mortality in high-risk patient subgroups', Andrology, 0 (ahead of print), pp. 1 - 9. doi: 10.1111/andr.13582. | en_US |
dc.identifier.issn | 2047-2919 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28212 | - |
dc.description | Data availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. | en_US |
dc.description | [Correction added on 12 January 2024, after first online publication: Figure 1 updated in this version.] | - |
dc.description.abstract | Objectives: We describe studies determining the association between testosterone therapy (TTh) and mortality. Materials & methods: We used a registry database of 737 men with adult-onset testosterone deficiency defined as presenting with low serum total testosterone (TT) levels ≤12.1 nmol/L and associated symptoms over a near 10-year follow-up. We compared associations between testosterone undecanoate (TU), cardio-metabolic risk factors and mortality using non-parametric statistics followed by separate Cox regression models to determine if any association between TU and morality was independent of age and cardio-metabolic risk factors. Finally, the association between TU and mortality was studied in men stratified by cardio-metabolic risk. Results: During a median follow-up interquartile range (IQR) of 114 (84–132) months, 94 of the 737 men died. TU (ref: non-treatment) was associated with mortality; hazard ratio = 0.23, 95% confidence intervals = 0.14–0.40. Cox's regression models showed the above association to be independent of baseline age, waist circumference, hemoglobin A1c, lipids, blood pressure, smoking, and type 2 diabetes. These variables remained associated with mortality. We finally stratified the men by the high-risk baseline variables and established that the association between mortality and TU was only evident in men at higher risk. A possible explanation could lie with the “law of initial value,” where greater improvements are evident following treatment in patients with worse baseline values. Conclusions: This study with long follow-up confirms that TTh is associated with lower mortality in men with adult-onset TD. This association was evident only in men with greater cardio-metabolic risk factors who demonstrated greater benefit. | en_US |
dc.description.sponsorship | North Staffordshire Medical Institute. Grant Number: PID-200078. | en_US |
dc.format.extent | 1 - 9 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley on behalf of American Society of Andrology and European Academy of Andrology | en_US |
dc.rights | Copyright © 2023 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | adult-onset testosterone deficiency | en_US |
dc.subject | all-cause mortality | en_US |
dc.subject | heterogeneity | en_US |
dc.subject | testosterone therapy | en_US |
dc.title | Testosterone replacement therapy: association with mortality in high-risk patient subgroups | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1111/andr.13582 | - |
dc.relation.isPartOf | Andrology | - |
pubs.issue | ahead of print | - |
pubs.publication-status | Published | - |
pubs.volume | 0 | - |
dc.identifier.eissn | 2047-2927 | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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FullText.pdf | Copyright © 2023 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 579.29 kB | Adobe PDF | View/Open |
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