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Title: | Recent Advances in 3D printing for in vitro cancer models |
Authors: | Zhang, B Morgan, M Teoh, XY Mackay, R Ermler, S Narayan, R |
Keywords: | 3D printing;Microfluidic devices;Bioengineering;Pharmaceuticals;Organs;Animal model;Cancer treatment;Cell lines;3D bioprinting |
Issue Date: | 14-Apr-2024 |
Publisher: | American Institute of Physics |
Citation: | Zhang, B. et al. (2024). ‘Recent advances in 3D printing for in vitro cancer models’ in Journal of Applied Physics. Vol.135 (14)., pp.1 - 19. DOI:https://doi.org/10.1063/5.0200726. |
Abstract: | 3D printing techniques allow for the precise placement of living cells, biological substances, and biochemical components, establishing themselves as a promising approach in bioengineering. Recently, 3D printing has been applied to develop human-relevant in vitro cancer models with highly controlled complexity and as a potential method for drug screening and disease modeling. Compared to 2D culture, 3D-printed in vitro cancer models more closely replicate the in vivo microenvironment. Additionally, they offer a reduction in the complexity and ethical issues associated with using in vivo animal models. This focused review discusses the relevance of 3D printing technologies and the applied cells and materials used in cutting-edge in vitro cancer models and microfluidic device systems. Future prospective solutions were discussed to establish 3D-printed in vitro models as reliable tools for drug screening and understanding cancer disease mechanisms. |
Description: | This paper is part of the special topic, Physics of 3D Printing. |
URI: | http://bura.brunel.ac.uk/handle/2438/28741 |
DOI: | http://dx.doi.org/10.1063/5.0200726 |
ISSN: | 0021-8979 |
Other Identifiers: | ORCiD ID Bin Zhang https://orcid.org/0000-0003-2374-0127 ORCiD ID Roger Narayan https://orcid.org/0000-0002-2673-0939 ORCiD ID Ruth Mackay https://orcid.org/0000-0002-6456-6914 ORCiD ID Sibylle Ermler https://orcid.org/0000-0002-2626-9548 ORCiD ID Meagan Morgan https://orcid.org/0000-0002-6637-9493 ORCiD ID Xin-Yi Teoh https://orcid.org/0000-0002-7548-0315 |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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