Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/28985
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Belluomo, I | - |
dc.contributor.author | Whitlock, SE | - |
dc.contributor.author | Myridakis, A | - |
dc.contributor.author | Parker, AG | - |
dc.contributor.author | Converso, V | - |
dc.contributor.author | Perkins, MJ | - |
dc.contributor.author | Langford, VS | - |
dc.contributor.author | Španěl, P | - |
dc.contributor.author | Hanna, GB | - |
dc.date.accessioned | 2024-05-13T10:26:47Z | - |
dc.date.available | 2024-05-13T10:26:47Z | - |
dc.date.issued | 2024-01-20 | - |
dc.identifier | ORCiD: Ilaria Belluomo https://orcid.org/0000-0002-8637-0285 | - |
dc.identifier | ORCiD: Antonis Myridakis https://orcid.org/0000-0003-1690-6651 | - |
dc.identifier | ORCiD: Valerio Converso https://orcid.org/0000-0002-3461-8891 | - |
dc.identifier | ORCiD: Vaughan S. Langford https://orcid.org/0000-0001-8059-5750 | - |
dc.identifier | ORCiD: Patrik Španěl https://orcid.org/0000-0002-9868-8282 | - |
dc.identifier.citation | Belluomo, I. et al. (2024) 'Combining Thermal Desorption with Selected Ion Flow Tube Mass Spectrometry for Analyses of Breath Volatile Organic Compounds', Analytical Chemistry, 96 (4), pp. 1397 - 1401. doi: 10.1021/acs.analchem.3c04286. | en_US |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28985 | - |
dc.description | Supporting Information is available online at: https://pubs.acs.org/doi/10.1021/acs.analchem.3c04286 . | en_US |
dc.description.abstract | An instrument integrating thermal desorption (TD) to selected ion flow tube mass spectrometry (SIFT-MS) is presented, and its application to analyze volatile organic compounds (VOCs) in human breath is demonstrated for the first time. The rationale behind this development is the need to analyze breath samples in large-scale multicenter clinical projects involving thousands of patients recruited in different hospitals. Following adapted guidelines for validating analytical techniques, we developed and validated a targeted analytical method for 21 compounds of diverse chemical class, chosen for their clinical and biological relevance. Validation has been carried out by two independent laboratories, using calibration standards and real breath samples from healthy volunteers. The merging of SIFT-MS and TD integrates the rapid analytical capabilities of SIFT-MS with the capacity to collect breath samples across multiple hospitals. Thanks to these features, the novel instrument has the potential to be easily employed in clinical practice. | en_US |
dc.description.sponsorship | This project was supported by Royal Society of Chemistry through the Research Fund. This research was also supported by Wellcome Trust, Surgery and Cancer Department, Imperial College London and NIHR London In Vitro Diagnostics Co-operative. | en_US |
dc.format.extent | 1397 - 1401 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | ACS Publications | en_US |
dc.rights | Copyright © 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Combining Thermal Desorption with Selected Ion Flow Tube Mass Spectrometry for Analyses of Breath Volatile Organic Compounds | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2023-12-26 | - |
dc.identifier.doi | https://doi.org/10.1021/acs.analchem.3c04286 | - |
dc.relation.isPartOf | Analytical Chemistry | - |
pubs.issue | 4 | - |
pubs.publication-status | Published | - |
pubs.volume | 96 | - |
dc.identifier.eissn | 1520-6882 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright © 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/). | 2.35 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License