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DC Field | Value | Language |
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dc.contributor.author | Kaur, A | - |
dc.contributor.author | Babaliari, E | - |
dc.contributor.author | Bolanos-Garcia, VM | - |
dc.contributor.author | Kefalogianni, M | - |
dc.contributor.author | Psilodimitrakopoulos, S | - |
dc.contributor.author | Kavatzikidou, P | - |
dc.contributor.author | Ranella, A | - |
dc.contributor.author | Ghorbani, M | - |
dc.contributor.author | Stratakis, E | - |
dc.contributor.author | Eskin, DG | - |
dc.contributor.author | Tzanakis, I | - |
dc.date.accessioned | 2025-05-09T15:47:30Z | - |
dc.date.available | 2025-05-09T15:47:30Z | - |
dc.date.issued | 2025-05-02 | - |
dc.identifier | ORCiD: Dmitry G. Eskin https://orcid.org/0000-0002-0303-2249 | - |
dc.identifier | Article number: 15396 | - |
dc.identifier.citation | Kaur, A. et al. (2025) 'Assessment of aqueous graphene as a cancer therapeutics delivery system', Scientific Reports, 15 (1), 15396, pp. 1 - 10. doi: 10.1038/s41598-025-98406-0. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/31200 | - |
dc.description | Data availability: The data that supports the findings of this study are available upon request from the corresponding authors. Correspondence and requests for materials should be addressed to AK and IT. | en_US |
dc.description.abstract | Graphene is a nanomaterial used in health and oncology settings. However, several reports have raised the alarm about potential toxicity. This study addressed this concern and determined the in vitro cytotoxicity of few-layer graphene (FLG) flakes produced in bespoke ultrasonic reactors using benign methods. The use of graphene flakes as a potential sensitising agent and a carrier for drug delivery in cancer cells was evaluated. To this end, aqueous based FLG suspensions were systematically characterised using UV-Vis, Raman spectroscopy and High-resolution Transmission electron microscopy (HR-TEM). Cell toxicity characterisation (e.g., cell viability assays using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and cell membrane integrity) of FLG in water were performed together with charge coupled device (CCD) and second harmonic generation (SHG) imaging of live cells in graphene solutions. Collectively, our findings show that NIH 3T3 mouse fibroblast and human fibroblast cells survival was higher than 80% and 90%, respectively upon treatment with the FLG fraction (~ 16 µg/ml ) recovered after centrifugation at 2000 revolutions per minute (RPM). In contrast, the cervical cancer cell line HeLa exposed to similar concentrations of FLG flakes resulted in approximately 30% cell death arguing in favour of a sensitising effect in cervical cancer cells. | en_US |
dc.description.sponsorship | This work was supported by NFFA EUROPE Pilot (EU H2020 framework programme) under grant agreement no.101007417 from 1/03/2021 to 28/02/2026/NFFA proposal ID-184, the Engineering and Physical Sciences Research Council (EPSRC) in the UK via the project “Sustainable and industrially scalable ultrasonic liquid phase exfoliation technologies for manufacturing 2D advanced functional materials” (EcoUltra2D), with the grant nos. EP/R031665/1; EP/R031401/1; EP/R031819/1; EP/R031975/1 and the Royal Society via the Isaac Newton International Fellowship to the project “Large Scale Exfoliation of 2D nanomaterials using an Environmentally Friendly Hybrid Cavitation Reactor” with grant number NIF\R1\221238 for providing financial support to this work. Also. Dr. Sotiris Psilodimitrakopoulos acknowledges MAYA – Project number: 014772. This project is carried out within the framework of the National Recovery and Resilience Plan Greece 2.0, funded by the European Union – Next Generation EU (Implementation body: HFRI). Mary Kefalogianni acknowledges the project Brain precision - TAEDR-0535850. This project is carried out within the framework of the National Recovery and Resilience Plan Greece 2.0, funded by the European Union – Next Generation EU. | en_US |
dc.format.extent | 1 - 10 | - |
dc.language | en | - |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Attribution 4.0 International | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | aqueous graphene | en_US |
dc.subject | ultrasonic liquid phase exfoliation | en_US |
dc.title | Assessment of aqueous graphene as a cancer therapeutics delivery system | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2025-04-11 | - |
dc.identifier.doi | https://doi.org/10.1038/s41598-025-98406-0 | - |
dc.relation.isPartOf | Scientific Reports | - |
pubs.publication-status | Published online | - |
pubs.volume | 15 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dcterms.dateAccepted | 2025-04-11 | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Brunel Centre for Advanced Solidification Technology (BCAST) |
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