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Title: Multi-scale interaction of flow and the artery wall
Authors: Halliday, I
Lishchuk, SV
Atherton, MA
Care, CM
Collins, MW
Evans, D
Evans, PC
Hose, DR
Khir, A
Krams, R
Lawford, PV
Ridger, V
Ventikos, Y
Walker, DC
Watton, PN
2nd Micro and Nano Flows Conference (MNF2009)
Keywords: Multi-scale;Microcirculation
Issue Date: 2009
Publisher: Brunel University
Citation: 2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009
Abstract: We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying their widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of flow, and proceed to propose, then validate (in practical, qualitative terms, at least) a multiply coupled, multi-scale modeling strategy, which, eventually, aims at a quantitative, patient-specific understanding of the coupling between the flow and the endothelial state.
ISBN: 978-1-902316-72-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
Mechanical and Aerospace Engineering
Dept of Mechanical Aerospace and Civil Engineering Research Papers

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