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Title: Huntington's disease: An immune perspective
Authors: Nayak, A
Ansar, R
Verma, SK
Bonifati, DM
Kishore, U
Issue Date: 2011
Publisher: Pubmed Central
Citation: Neurology Research International, 2011: 563784, 2011
Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.
Description: Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.
ISSN: 2090-1860
Appears in Collections:Biological Sciences
Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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