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Title: | Huntington's disease: An immune perspective |
Authors: | Nayak, A Ansar, R Verma, SK Bonifati, DM Kishore, U |
Issue Date: | 2011 |
Publisher: | Pubmed Central |
Citation: | Neurology Research International, 2011: 563784, 2011 |
Abstract: | Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD. |
Description: | Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund. |
URI: | http://bura.brunel.ac.uk/handle/2438/5852 |
DOI: | http://dx.doi.org/10.1155/2011/563784 |
ISSN: | 2090-1860 |
Appears in Collections: | Biological Sciences Publications Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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