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DC Field | Value | Language |
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dc.contributor.author | Maloy, KJ | - |
dc.contributor.author | Salaun, L | - |
dc.contributor.author | Cahill, R | - |
dc.contributor.author | Dougan, G | - |
dc.contributor.author | Saunders, NJ | - |
dc.contributor.author | Powrie, F | - |
dc.date.accessioned | 2012-09-14T14:44:49Z | - |
dc.date.available | 2012-09-14T14:44:49Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Experimental Medicine, 197(1): 111-119, Jan 2003 | en_US |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://jem.highwire.org/content/197/1/111.abstract | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/6663 | - |
dc.description | Copyright @ 2003 The Rockefeller University Press | en_US |
dc.description.abstract | CD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG)−/− mice as a model to study the ability of CD4+CD25+ TR cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell–independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4+CD25+ TR cells. T cell–independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4+CD25+ TR cells. Suppression of innate immune pathology was dependent on T cell–derived interleukin 10 and also on the production of transforming growth factor β. Thus, CD4+CD25+ TR cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms. | en_US |
dc.description.sponsorship | This project was supported by a Wellcome Trust Project grant (F. Powrie) and by Wellcome Trust Fellowships (F. Powrie and N.J. Saunders). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.subject | Regulatory T cells | en_US |
dc.subject | Helicobacter | en_US |
dc.subject | Immune tolerance | en_US |
dc.subject | Mucosal immunity | en_US |
dc.subject | IL-10 | en_US |
dc.title | CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1084/jem.20021345 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care/Biological Sciences | - |
pubs.organisational-data | /Brunel/Group Publication Pages | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Publications Dept of Life Sciences Research Papers |
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