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DC Field | Value | Language |
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dc.contributor.author | Benner, MF | - |
dc.contributor.author | Ballabio, E | - |
dc.contributor.author | van Kester, MS | - |
dc.contributor.author | Saunders, NJ | - |
dc.contributor.author | Vermeer, MH | - |
dc.contributor.author | Willemze, R | - |
dc.contributor.author | Lawrie, CH | - |
dc.contributor.author | Tensen, CP | - |
dc.date.accessioned | 2012-09-17T09:25:34Z | - |
dc.date.available | 2012-09-17T09:25:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Experimental Dermatology, 21(8): 632 - 634, Aug 2012 | en_US |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2012.01548.x/abstract | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/6670 | - |
dc.description | Copyright @ 2012 John Wiley & Sons | en_US |
dc.description.abstract | The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoides (MF). We identified 13 differentially expressed miRNAs between C-ALCL and BID. The up-regulation of miR-155, miR-27b, miR-30c and miR-29b in C-ALCL was validated by miRNA-Q-PCR on independent study groups. Additionally, the miRNA expression profiles of C-ALCL were compared with those of tumor-stage MF. Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL. This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas. | en_US |
dc.description.sponsorship | This work was funded by grants from Netherlands Organization for Scientific Research (NWO) (MHV) and the Fondation ReneĀ“ Touraine (MvK), and grants from the Leukaemia and Lymphoma Research (EB) and the Julian Starmer-Smith Memorial Fund (CHL). | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley and Sons | en_US |
dc.subject | miR-155 | en_US |
dc.subject | miRNA microarray | en_US |
dc.subject | Mycosis fungoides | en_US |
dc.subject | Primary cutaneous anaplastic large cell lymphoma | en_US |
dc.subject | Q-PCR | en_US |
dc.title | Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1111/j.1600-0625.2012.01548.x | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Publications Dept of Life Sciences Research Papers |
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