Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/7711
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nayak, A | - |
dc.contributor.author | Dodagatta-Marri, E | - |
dc.contributor.author | Tsolaki, AG | - |
dc.contributor.author | Kishore, U | - |
dc.date.accessioned | 2013-11-26T10:06:26Z | - |
dc.date.available | 2013-11-26T10:06:26Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Front Immunol, 3, 131, 2012 | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22701116 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/7711 | - |
dc.description | PMCID: PMC3369187 | en_US |
dc.description.abstract | Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands on pathogens, allergens, and apoptotic cells, via C-terminal homotrimeric carbohydrate recognition domains, while the collagen region brings about the effector functions via its interaction with cell surface receptors. SP-A and SP-D deal with various pathogens, using a range of innate immune mechanisms such as agglutination/aggregation, enhancement of phagocytosis, and killing mechanisms by phagocytic cells and direct growth inhibition. SP-A and SP-D have also been shown to be involved in the control of pulmonary inflammation including allergy and asthma. Emerging evidence suggest that SP-A and SP-D are capable of linking innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. This review enumerates immunological properties of SP-A and SP-D inside and outside lungs and discusses their importance in human health and disease. | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers | en_US |
dc.subject | Hypersensitivity | en_US |
dc.subject | Infection | en_US |
dc.subject | Innate immunity | en_US |
dc.subject | Macrophage | en_US |
dc.subject | Pattern recognition receptor | en_US |
dc.subject | Surfactant | en_US |
dc.title | An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.3389/fimmu.2012.00131 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Health Sciences & Social Care/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Infection, Immunity and Disease Mechanisms | - |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 917 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.