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dc.contributor.authorSlater, TF-
dc.contributor.authorCheeseman, KH-
dc.contributor.authorBenedetto, C-
dc.contributor.authorCollins, MW-
dc.contributor.authorEmery, S-
dc.contributor.authorMaddix, SP-
dc.contributor.authorNodes, JT-
dc.contributor.authorProudfoot, K-
dc.contributor.authorBurton, GW-
dc.contributor.authorIngold, KU-
dc.identifier.citationBiochem J. 1990 Jan 1; 265(1): 51-59en
dc.description.abstractUsing the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark phase, partial hepatectomy is followed by a rapid regeneration of liver mass with cycles of synchronized cell division at 24 h intervals. The latter phenomenon is indicated in this study by pulses of thymidine kinase activity having maxima at 24 h, 48 h and 72 h after partial hepatectomy. Microsomes prepared from regenerating livers show changes in lipid peroxidation activity (induced by NADPH/ADP/iron or by ascorbate/iron), which is significantly decreased relative to that in microsomes from sham-operated controls, again at 24 h, 48 h and 72 h after the operation. This phenomenon has been investigated with regard to possible underlying changes in the content of microsomal fatty acids, the microsomal enzymes NADPH:cytochrome c reductase and cytochrome P-450, and the physiological microsomal antioxidant alpha-tocopherol. The cycles of decreased lipid peroxidation activity are apparently due, at least in part, to changes in microsomal alpha-tocopherol content that are closely associated in time with thymidine kinase activity.en
dc.format.extent1647113 bytes-
dc.publisherThe Biochemical Societyen
dc.titleStudies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspectsen
dc.typeResearch Paperen
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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