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DC Field | Value | Language |
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dc.contributor.author | Slater, TF | - |
dc.contributor.author | Cheeseman, KH | - |
dc.contributor.author | Benedetto, C | - |
dc.contributor.author | Collins, MW | - |
dc.contributor.author | Emery, S | - |
dc.contributor.author | Maddix, SP | - |
dc.contributor.author | Nodes, JT | - |
dc.contributor.author | Proudfoot, K | - |
dc.contributor.author | Burton, GW | - |
dc.contributor.author | Ingold, KU | - |
dc.coverage.spatial | 9 | en |
dc.date.accessioned | 2007-05-24T14:55:21Z | - |
dc.date.available | 2007-05-24T14:55:21Z | - |
dc.date.issued | 1990 | - |
dc.identifier.citation | Biochem J. 1990 Jan 1; 265(1): 51-59 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/799 | - |
dc.description.abstract | Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark phase, partial hepatectomy is followed by a rapid regeneration of liver mass with cycles of synchronized cell division at 24 h intervals. The latter phenomenon is indicated in this study by pulses of thymidine kinase activity having maxima at 24 h, 48 h and 72 h after partial hepatectomy. Microsomes prepared from regenerating livers show changes in lipid peroxidation activity (induced by NADPH/ADP/iron or by ascorbate/iron), which is significantly decreased relative to that in microsomes from sham-operated controls, again at 24 h, 48 h and 72 h after the operation. This phenomenon has been investigated with regard to possible underlying changes in the content of microsomal fatty acids, the microsomal enzymes NADPH:cytochrome c reductase and cytochrome P-450, and the physiological microsomal antioxidant alpha-tocopherol. The cycles of decreased lipid peroxidation activity are apparently due, at least in part, to changes in microsomal alpha-tocopherol content that are closely associated in time with thymidine kinase activity. | en |
dc.format.extent | 1647113 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | The Biochemical Society | en |
dc.title | Studies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects | en |
dc.type | Research Paper | en |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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Hyperplasia rat liver.pdf | 1.61 MB | Adobe PDF | View/Open |
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