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Title: In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors
Authors: Pal, C
Cammidge, AN
Cook, MJ
Sosa-Sanchez, JL
Sharma, AK
Ray, AK
Keywords: Lutetium bisphthalocyanine;UV–visible absorption;Biomolecules;Chemichromic changes;Rate of reduction
Issue Date: 2012
Publisher: The Royal Society
Citation: Journal of the Royal Society Interface, 9(66), 183 - 189, 2012
Abstract: Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.
Description: This article is available open access through the publisher’s website at the link below. Copyright @ 2011 The Royal Society.
ISSN: 1742-5662
Appears in Collections:Wolfson Centre for Materials Processing
Dept of Mechanical Aerospace and Civil Engineering Research Papers

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