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dc.contributor.authorMüller, K-
dc.contributor.authorFedosov, DA-
dc.contributor.authorGompper, G-
dc.contributor.author4th Micro and Nano Flows Conference (MNF2014)-
dc.identifier.citation4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabanien_US
dc.descriptionThis paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community,
dc.description.abstractThe von Willebrand factor (vWF), a large multimeric protein, is essential in hemostasis. Under normal conditions, vWF is present in blood as a globular polymer. However, in case of an injury, vWF is able to unwrap and bind to the vessel wall and to flowing platelets. Thus, platelets are significantly slowed down and can adhere to the wall and close the lesion. Nevertheless, it is still not clear how the unwrapping of the vWF is triggered. To better understand these complex processes, we employ a particle-based hydrodynamic simulation method to study the behaviour of vWF in blood flow. The vWF is modelled as a chain of beads (monomers) connected by springs. In addition, the monomers are subject to attractive interactions in order to represent characteristic properties of the vWF. The behaviour of vWF is investigated under different conditions including a freely-suspended polymer in shear flow and a polymer attached to a wall. We also examine the migration of vWF to a wall (margination) depending on shear rate and volume fraction of red blood cells (RBCs). Furthermore, the stretching of the vWF in flow direction depending on its radial position in a capillary is monitored. Our results show that attractive interactions between monomer beads increase margination efficiency and significantly affect the extension of vWF at different radial positions in blood vessels.en_US
dc.publisherBrunel University Londonen_US
dc.relation.ispartofseriesID 178-
dc.subjectPrimary Hemostasisen_US
dc.subjectMargination probabilityen_US
dc.subjectNumerical modellingen_US
dc.subjectDissipative particle dynamicsen_US
dc.titleBehaviour of the von Willebrand Factor in Blood Flowen_US
dc.typeConference Paperen_US
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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