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Title: Behaviour of the von Willebrand Factor in Blood Flow
Authors: Müller, K
Fedosov, DA
Gompper, G
4th Micro and Nano Flows Conference (MNF2014)
Keywords: Primary Hemostasis;Polymer;Margination probability;Numerical modelling;Dissipative particle dynamics
Issue Date: 2014
Publisher: Brunel University London
Citation: 4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabani
Series/Report no.: ID 178
Abstract: The von Willebrand factor (vWF), a large multimeric protein, is essential in hemostasis. Under normal conditions, vWF is present in blood as a globular polymer. However, in case of an injury, vWF is able to unwrap and bind to the vessel wall and to flowing platelets. Thus, platelets are significantly slowed down and can adhere to the wall and close the lesion. Nevertheless, it is still not clear how the unwrapping of the vWF is triggered. To better understand these complex processes, we employ a particle-based hydrodynamic simulation method to study the behaviour of vWF in blood flow. The vWF is modelled as a chain of beads (monomers) connected by springs. In addition, the monomers are subject to attractive interactions in order to represent characteristic properties of the vWF. The behaviour of vWF is investigated under different conditions including a freely-suspended polymer in shear flow and a polymer attached to a wall. We also examine the migration of vWF to a wall (margination) depending on shear rate and volume fraction of red blood cells (RBCs). Furthermore, the stretching of the vWF in flow direction depending on its radial position in a capillary is monitored. Our results show that attractive interactions between monomer beads increase margination efficiency and significantly affect the extension of vWF at different radial positions in blood vessels.
Description: This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community,
ISBN: 978-1-908549-16-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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