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DC Field | Value | Language |
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dc.contributor.author | Rausanu, S | - |
dc.contributor.author | Grosan, C | - |
dc.contributor.author | Wu, Z | - |
dc.contributor.author | Parvu, O | - |
dc.contributor.author | Stoica, R | - |
dc.contributor.author | Gilbert, D | - |
dc.date.accessioned | 2014-12-19T12:08:01Z | - |
dc.date.available | 2014-06-12 | - |
dc.date.available | 2014-12-19T12:08:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Neural Computing and Applications, (12 June 2014) | en_US |
dc.identifier.issn | 0941-0643 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs00521-014-1617-x | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/9575 | - |
dc.description.abstract | Biochemical networks are of great practical importance. The interaction of biological compounds in cells has been enforced to a proper understanding by the numerous bioinformatics projects, which contributed to a vast amount of biological information. The construction of biochemical systems (systems of chemical reactions), which include both topology and kinetic constants of the chemical reactions, is NP-hard and is a well-studied system biology problem. In this paper, we propose a hybrid architecture, which combines genetic programming and simulated annealing in order to generate and optimize both the topology (the network) and the reaction rates of a biochemical system. Simulations and analysis of an artificial model and three real models (two models and the noisy version of one of them) show promising results for the proposed method. | en_US |
dc.description.sponsorship | The Romanian National Authority for Scientific Research, CNDI–UEFISCDI, Project No. PN-II-PT-PCCA-2011-3.2-0917. | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Springer London | en_US |
dc.subject | Biochemical systems | en_US |
dc.subject | Genetic programming | en_US |
dc.subject | Optimization | en_US |
dc.subject | Petri nets | en_US |
dc.subject | Simulated annealing | en_US |
dc.subject | Systems biology | en_US |
dc.title | Computational models for inferring biochemical networks | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00521-014-1617-x | - |
dc.relation.isPartOf | Neural Computing and Applications | - |
dc.relation.isPartOf | Neural Computing and Applications | - |
pubs.publication-status | Accepted | - |
pubs.publication-status | Accepted | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Computer Science | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Computer Science/Computer Science | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/Brunel Business School - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/Brunel Business School - URCs and Groups/Centre for Research into Entrepreneurship, International Business and Innovation in Emerging Markets | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Information Systems, Computing and Mathematics - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Information Systems, Computing and Mathematics - URCs and Groups/Multidisclipary Assessment of Technology Centre for Healthcare (MATCH) | - |
Appears in Collections: | Dept of Computer Science Research Papers |
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Fulltext.pdf | 925.95 kB | Adobe PDF | View/Open |
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