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DC Field | Value | Language |
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dc.contributor.author | Mparmpakas, D | - |
dc.contributor.author | Zachariades, E | - |
dc.contributor.author | Sotiriadis, G | - |
dc.contributor.author | Goumenou, A | - |
dc.contributor.author | Harvey, AJ | - |
dc.contributor.author | Gidron, Y | - |
dc.contributor.author | Karteris, E | - |
dc.coverage.spatial | United States | - |
dc.date.accessioned | 2014-12-23T13:23:05Z | - |
dc.date.available | 2014 | - |
dc.date.available | 2014-12-23T13:23:05Z | - |
dc.date.issued | 2014-05-11 | - |
dc.identifier.citation | Mparmpakas, D., Zachariades, E., Sotiriadis, G., Goumenou, A., Harvey, A.J., Gidron, Y. and Karteris, E. 'Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress.', (2014) Obstetrics and Gynecology International, 2014, 239278 pp. 1-9 . doi:10.1155/2014/239278. | en_US |
dc.identifier.issn | 1687-9589 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/9626 | - |
dc.description | This article has been made available through the Brunel Open Access Publishing Fund. | - |
dc.description.abstract | Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction that can influence fetal birth weight. This study examined the relationship between mothers' stress and attitude towards their pregnancies, placental glucocorticoid receptors (GRs) and growth arrest-specific transcript 5 (GAS5) expression, and the status of GR polymorphism, with their infants' birth weights. GAS5 and GR α were the predominant transcripts in both term and preterm placentas, with GAS5 being primarily localized in the syncytiotrophoblasts. In an attempt to mimic moderate and high stress environment in vitro, BeWo and JEG-3 cytotrophoblast cell lines were treated with 10 nM-1000 nM cortisol. Only expression of GAS5 was significantly upregulated by cortisol in all treatments compared with basal levels, but none of the GRs changed expression significantly. In an attempt to assess a stress versus gene interaction, we studied four GR polymorphisms. In the homozygous group for Tth111I polymorphism, mothers with negative attitudes towards the pregnancy gave birth to infants with significantly lower birth weights compared to women with positive/neutral attitudes. None of the GR splice variants were associated with maternal stress. However, placental GAS5 levels were inversely correlated with maternal stress. This study points towards a potential gene-environment interaction that could be of predictive value for fetal weight. | en_US |
dc.description.sponsorship | Brunel Open Access Publishing Fund | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | - |
dc.subject | maternal stress | en_US |
dc.subject | polymorphism | en_US |
dc.subject | birth outcomes | en_US |
dc.title | Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1155/2014/239278 | - |
dc.relation.isPartOf | Obstet Gynecol Int | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health and Environment | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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