Targeting de novo purine biosynthesis for tuberculosis treatment See

Tuberculosis remains the leading cause of death from an infectious disease1,2. Here we report the discovery of a first-in-class small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway. The lead candidate, JNJ-6640, exhibited nanomolar bac...

Respiratory bioenergetics is enhanced in human, but not bovine macrophages after exposure to M. bovis PPD: Exploratory insights into overall similar Cellular Metabolic Profiles See

The role of macrophage (MØ) cellular metabolism and reprogramming during TB infection is of great interest due to the influence of Mycobacterium spp. on MØ bioenergetics. Recent studies have shown that M. tuberculosis induces a TLR2-dependent shift towards aerobic glycolysis, comparable to&#...

Memorandum submitted to the House of Commons Energy Security and Net-zero Select Committee for their inquiry on: Revisiting the nuclear roadmap See

Summary: Under the assumptions currently driving HM Government policy, it is impossible to meet the stated target of 24 GW of new nuclear by 2050. We estimate that 15.9 GW is the likely maximum possible installed capacity for large-scale nuclear. Furthermore, the investment require...

Assessing the knowledge and compliance of Quality Management practice among Ghanaian Construction Organisations See

Construction organisations are using Quality Management Systems (QMS) increasingly as a strategy to address issues with quality in their sector to satisfy end-user requirements. Unfortunately, construction projects in Ghana constantly face lack of quality management practices. This study aimed to ...

Structure and Tribological Performance of diamond-like carbon based coatings for aerospace component processing See

Conventional electroplating processes, such as hard chromium plating, are extensively used on aircraft components to improve their functionality and reduce wear. While hard chrome plating offers certain benefits, it also has some categorical disadvantages. Being a known carcinogen and...

Gender Politics in Nigeria: A Socio-Political Analysis of Women’s Perspectives on Feminism, Feminist Politics, and Democracy See

Nigeria’s democracy exhibits gender-based inequalities that suppress women’s voices and disproportionately under-represent them inpolitical leadership. Using feminist political philosophy as its theoretical framework, and mixed methods to gather data, this study interrogated Nigerian feminism, feminist politics, and...

User-Centered Artificial Intelligence for Game Design and Development with the GAGeTx framework: Graphical Asset Generation and Transformation See

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Mutual Trust in Judicial Cooperation in Criminal Matters See

1. Mutual trust has been acclaimed by the Court of Justice of the European Union (CJEU) as a ‘the raison d’être of the European Union and the creation of an area of freedom, security and justice’, signifying the fundamental significance of it (Joined cases C-411/10 a...

Acute and brief air pollution exposure impairs personal and social well-being and quality of life: empirical evidence from India See

Air pollution is well-documented to negatively impact mental health, but its effects on positive mental health indicators, including quality of life (QOL) and personal and social well-being (PSWB), remain underexplored. This study examined the relationships between acute (24-hour) and brief (7-&#...