Primary healthcare costs associated with the AstraZeneca COVID-19 vaccine in England See

Current research on the effectiveness of COVID-19 vaccines has demonstrated their role in reducing hospitalizations and deaths due to SARS-CoV-2. However, evidence regarding the healthcare costs incurred by vaccinated versus unvaccinated individuals in the community remains limited, especially in prim...

Inspiratory muscle training in the healthy adult: The relationship between load, perception, and oxygen consumption See

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Modelling the impact of Bikeability cycle training on the number of people killed or seriously injured on UK roads See

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Epigenomic subtyping of late‐onset Alzheimer's disease reveals distinct microglial signatures and molecular inflammatory phenotypes See

Background: Growing evidence suggests that the heterogeneity of late-onset Alzheimer's disease (LOAD) plays a significant role in treatment failure. In recent years, molecular subtyping of AD has increasingly leveraged omics data to uncover distinct molecular profiles that may underlie ...

Atypical antipsychotic prescription for agitation in care homes: A qualitative study exploring views of residents, relatives and health and social care professionals See

Atypical antipsychotics are either unlicensed or licensed with restrictions on duration and indication in many jurisdictions including USA, Canada, Europe and Australia. Despite this, prescribing data suggest regular use off label but the reasons for this are unclear. Exploring these reasons ...

The measurement of agitation in neurocognitive disorders: A systematic review See

Background Agitation is a common and distressing behavior in persons with neurocognitive disorders. However, efforts to understand and develop interventions for agitation, historically considered only as a symptom, have been complicated by heterogeneity in the definition, identification, and measurem...

Plasma biomarkers in neuropsychiatric syndromes: A narrative review See

Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding biomarkers. Further, emerging evidence describes the utility of systematic assessment of NPS across the cognitive continuum, even in advance of&...

Sleep-Related Disturbances, Psychosis, and Cognitive Decline in Healthy Older Adults: A Cross Sectional Analysis of PROTECT Study Data See

BACKGROUND: Sleep-related disturbances are commonly reported in approximately 50% of older adults and have been associated with various psychiatric (e.g., psychosis) and neurodegenerative disorders (e.g., dementia). While the overlapping relationships between psychosis and sleep-related disturbances in cognitive...

Termination of DNA replication drives genomic instability via multiple mechanisms See

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