Cleaving DNA with DNA: Cooperative Tuning of Structure and Reactivity Driven by Copper Ions See

A copper-dependent self-cleaving DNA (DNAzyme or deoyxyribozyme) previously isolated by in vitro selection has been analyzed by a combination of Molecular Dynamics (MD) simulations and advanced Electron Paramagnetic Resonance (Electron Spin Resonance) EPR/ESR spectroscopy, providing insights on the st...

Move Together Buckinghamshire: Protocol for a Pragmatic Mixed-Methods Evaluation of a Community Physical Activity Programme for Older Adults with Long-Term Conditions See

Introduction Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (PERFORM) is a research programme that seeks to develop and evaluate a comprehensive exercise-based rehabilitation intervention designed for people with multimorbidity, the presence of multiple long-term conditions (MLTCs...

Lifecycle emissions of hydrogen supply chains in China: A spatially resolved assessment See

Current hydrogen delivery assessments exhibit incomplete supply chain coverage, insufficient carrier diversity, and oversimplified spatial analysis relying on hypothetical distances. This study addresses these limitations through comprehensive life cycle assessment across China's four major transport routes for&...

Hydrogen applications in buildings: A systematic review of decarbonization pathways See

The building sector is a major contributor to global energy use and carbon emissions, positioning it as a key target for decarbonization. Hydrogen, as a clean and flexible energy carrier, offers significant potential in supporting this transition. This review synthesizes recent advances ...

Flow boiling critical heat flux in MICRO-scale heat sinks and comparison with correlations See

The growing demand for high-performance miniature electronics is forcing the heat dissipation requirements to increasingly higher levels. Flow boiling in micro-scale heat exchangers is a good choice for cooling these high heat flux devices. In such systems, the prediction of critical heat&#x...

Generation of 3D Hemogenic Gastruloids From Mouse Embryonic Stem Cells See

Embryonic blood formation encompasses the independent generation of different cell types in distinct cellular and anatomical environments, reflecting highly coordinated specific hierarchies of interacting tissues. Despite widespread use of embryonic stem cells (ESC) and induced pluripotent stem cell (iPSC)...

Rapid Identification of Pathogenic Bacteria from Raman Spectra with a CNN–Transformer Hybrid Architecture See

Bacterial identification from Raman spectra offers a promising label-free and nondestructive approach, providing molecular fingerprints at the single-cell level. However, practical implementation is constrained by low signal-to-noise ratios arising from short acquisition times, severe class imbalance across bac...

Gen-AI and Trade Marks: Ascertaining Liability from a UK and EU Perspective See

Over recent years, generative AI (gen-AI) technology has infiltrated society, from AI text generators being viewed as the evolution of search engines to the ever-increasing AI generation of image and media content by online users. Yet the latter often contains signs that are identi...

Computation Model of Electrostatic Spraying in Agriculture Industry See

Introduction: Agricultural chemicals such as pesticides are used to protect plants against insects and diseases. In this project, electrostatic spray is investigated with intelligent sensors for efficient use of pesticides. As a part of this project, COMSOL Multiphysics® model was developed ...