3-(Pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives: synthesis, <i>Mycobacterium tuberculosis</i> CYP121A1 enzyme inhibition and antimycobacterial activity <i>vs</i> drug-sensitive and drug-resistant strains See

CYP121A1 is a promising cytochrome P450 (CYP) drug target in <i>Mycobacterium tuberculosis (Mtb)</i> owing to its physiological importance in bacterial cell viability. The continuing rise of multidrug resistant (MDR) and extremely drug resistant (XDR) tuberculosis (TB), offers potential th...

Rationalisation of steel grades and specifications using machine learning techniques See

There are an excessive number of steel grades currently in use. However, many of them are used in the same application despite differences in chemical composition and processing conditions, and in some cases shows equivalent ranges of properties. These huge number of grades poses&#...

Identification of multiple Acinetobacter baumannii protein antigens as targets for potential immunotherapies using a novel protein microarray screening approach See

The World Health Organisation has identified Acinetobacter baumannii as a critical priority antimicrobial resistant (AMR) pathogen for which new therapeutics are needed. Despite this, currently there are no antibody or vaccine candidates in advanced clinical development for A. baumannii. To help&...

Dissemination of extended-spectrum beta-lactamase-producing Escherichia coli in poultry in Zimbabwe See

Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are resistant to the critically important third- and fourth-generation cephalosporin antibiotics and present a risk to animal and human health. In Zimbabwe, there is an evidence gap concerning the prevalence and diversity of ESBL-producing&...

Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis See

The antibiotic resistance crisis has created an urgent need for the development of novel therapeutic strategies to tackle recalcitrant infections. In this study, we identified Tormentil [Potentilla erecta (L.) Raeusch.], a plant that has been used in traditional medicine for centuries, as&#x...

Network-level divergence in cyclic di-GMP signalling drives ecological versatility in Acinetobacter baumannii See

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The ExtRA Capacity Test: Reliability, validity and normative data of a new clinical tool for assessing shoulder muscle performance See

Objectives: Introduce The ExtRA Capacity Test, a measure for assessing shoulder muscle performance. Assess its reliability, validity and present normative scores in a large sample of asymptomatic adults. Design: Cross-sectional observational study with test–retest. Setting: ...

Navigating Challenges, Embracing Opportunities: An Assessment of Women’s Leadership and Career Advancement in Africa, with a Focus on Nigeria See

A gendered ideology and a gendered hierarchy are prominent components that impact African women’s leadership and career advancement. By considering extant literature, empirical evidence, and expert insights on this topic, the aim of this chapter is to understand the dynamics surrounding wome...

The BBC is a partisan battleground – why does Japan’s public broadcaster escape the same fate? See

Public service broadcasters are supposed to be the most trusted news outlets in democratic societies. Funded through models like licence fees and free from advertising, they are meant to stand apart from commercial media