The Cerebral Palsy Link Worker (CP LINK) study: Protocol for a feasibility study with integrated process evaluation See

Background: Cerebral palsy (CP) is the most common lifelong physical disability in the UK and is linked to multiple social, psychological and health inequalities which are often amplified as this group ages. Most middle-aged and older people with CP are supported in their&#x...

Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells See

<jats:p>ERK is a key signaling mediator controlling both proliferation and lineage specification during embryo development. How ERK choreographs differentiation and proliferation to achieve balanced developmental outcomes in lineages with variable ERK activities remains unclear. To investigate this, we&#x...

Evaluation of variant calling algorithms for wastewater-based epidemiology using mixed populations of SARS-CoV-2 variants in synthetic and wastewater samples See

Wastewater-based epidemiology has been used extensively throughout the COVID-19 (coronavirus disease 19) pandemic to detect and monitor the spread and prevalence of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and its variants. It has proven an excellent, complementary tool to cli...

The Antimicrobial Peptide, Bactenecin 5, Supports Cell-Mediated but Not Humoral Immunity in the Context of a Mycobacterial Antigen Vaccine Model See

Bactenecin (Bac) 5 is a bovine antimicrobial peptide (AMP) capable of killing some species of bacteria through the inhibition of protein synthesis. Bac5 and other AMPs have also been shown to have chemotactic properties and can induce inflammatory cytokine expression by innate immune&#x...

Analysing Residual Stresses in Wind Turbine Blade Repair: A Hole Drill Method and Digital Image Correlation Approach See

The primary reason for residual stresses in the wind turbine blade during the repair process is mismatch between the chemical shrinkage and thermal expansion coefficients of the base composite (blade) and the patch. These residual stresses have the potential to compromise structural int...

Ultraviolet (UV) curable resin-based repair of wind turbine blades: Perspectives and computational analysis See

The repair of wind turbine blades is essential for extending their operational lifespan by restoring their structural integrity after property degradation due to damage. Application of ultraviolet (UV)-curable prepregs in the repair process reduces curing time from hours to minutes compared ...

A Comprehensive Design and Simulation of Highly Inductive Bi-directional Wireless Power Transfer See

This paper presents the design and optimization of a Bidirectional Wireless Power Transfer (BWPT) system for electric vehicles (EVs), enabling efficient two-way energy exchange between the grid and vehicle. The proposed system integrates with smart grids and renewable sources, enhancing sustainab...

Psychedelic layerings: Fluid identities of a self-placed young Chinese immigrant in the U.K. See

This study aims to explore the complex interplay of cultural identity and artistic expression, situated within my personal experiences in the UK, in which I have imagined or self-placed myself as a young Chinese immigrant through the lens of cultural identity within my privilege&#x...

3-(Pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives: synthesis, <i>Mycobacterium tuberculosis</i> CYP121A1 enzyme inhibition and antimycobacterial activity <i>vs</i> drug-sensitive and drug-resistant strains See

CYP121A1 is a promising cytochrome P450 (CYP) drug target in <i>Mycobacterium tuberculosis (Mtb)</i> owing to its physiological importance in bacterial cell viability. The continuing rise of multidrug resistant (MDR) and extremely drug resistant (XDR) tuberculosis (TB), offers potential th...