Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/10071
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Haverkamp, HC | - |
dc.contributor.author | Amann, M | - |
dc.contributor.author | Lovering, AT | - |
dc.contributor.author | Pegelow, DF | - |
dc.contributor.author | Dempsey, JA | - |
dc.date.accessioned | 2015-01-22T14:22:18Z | - |
dc.date.accessioned | 2015-02-03T10:48:00Z | - |
dc.date.available | 2007 | - |
dc.date.available | 2015-02-03T10:48:00Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292:1, pp. R598 - R606, 2007 | en_US |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.uri | http://ajpregu.physiology.org/content/292/1/R598 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/10071 | - |
dc.description.abstract | We hypothesized that severe hypoxia limits exercise performance via decreased contractility of limb locomotor muscles. Nine male subjects [mean ± SE maximum O2 uptake (V̇o2 max) = 56.5 ± 2.7 ml·kg−1·min−1] cycled at ≥90% V̇o2 max to exhaustion in normoxia [NORM-EXH; inspired O2 fraction (FiO2) = 0.21, arterial O2 saturation (SpO2) = 93 ± 1%] and hypoxia (HYPOX-EXH; FiO2 = 0.13, SpO2 = 76 ± 1%). The subjects also exercised in normoxia for a time equal to that achieved in hypoxia (NORM-CTRL; SpO2 = 96 ± 1%). Quadriceps twitch force, in response to supramaximal single (nonpotentiated and potentiated 1 Hz) and paired magnetic stimuli of the femoral nerve (10–100 Hz), was assessed pre- and at 2.5, 35, and 70 min postexercise. Hypoxia exacerbated exercise-induced peripheral fatigue, as evidenced by a greater decrease in potentiated twitch force in HYPOX-EXH vs. NORM-CTRL (−39 ± 4 vs. −24 ± 3%, P < 0.01). Time to exhaustion was reduced by more than two-thirds in HYPOX-EXH vs. NORM-EXH (4.2 ± 0.5 vs. 13.4 ± 0.8 min, P < 0.01); however, peripheral fatigue was not different in HYPOX-EXH vs. NORM-EXH (−34 ± 4 vs. −39 ± 4%, P > 0.05). Blood lactate concentration and perceptions of limb discomfort were higher throughout HYPOX-EXH vs. NORM-CTRL but were not different at end-exercise in HYPOX-EXH vs. NORM-EXH. We conclude that severe hypoxia exacerbates peripheral fatigue of limb locomotor muscles and that this effect may contribute, in part, to the early termination of exercise. | en_US |
dc.format.extent | R598 - R606 | - |
dc.format.extent | R598 - R606 | - |
dc.format.extent | R598 - R606 | - |
dc.language.iso | en | en_US |
dc.relation.replaces | http://bura.brunel.ac.uk/handle/2438/9911 | - |
dc.relation.replaces | 2438/9911 | - |
dc.subject | Severe hypoxia | en_US |
dc.subject | Limb locomotor muscles | en_US |
dc.title | Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1152/ajpregu.00269.2006 | - |
dc.relation.isPartOf | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | - |
dc.relation.isPartOf | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | - |
dc.relation.isPartOf | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | - |
pubs.issue | 1 | - |
pubs.issue | 1 | - |
pubs.issue | 1 | - |
pubs.volume | 292 | - |
pubs.volume | 292 | - |
pubs.volume | 292 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Sport Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Notice.pdf | 44.44 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.