Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/10082
Title: Erratum to: The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer.
Authors: Bridger, JM
Arican-Gotkas, HD
Foster, HA
Godwin, LS
Harvey, A
Kill, IR
Knight, M
Mehta, IS
Ahmed, MH
Keywords: chromosome positioning;gene positioning;gene expression;nuclear envelope;nuclear lamins
Issue Date: 24-Jan-2014
Citation: Bridger J.M. et al. (2014) 'ERRATUM TO: The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and Its Relevance in Disease, Infection, Aging, and Cancer', in: Schirmer E., de las Heras J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773, pp. E1-E1. Springer, New York, NY. doi: 10.1007/978-1-4899-8032-8_28.
Abstract: The genomes of a wide range of different organisms are non-randomly organized within interphase nuclei. Chromosomes and genes can be moved rapidly, with direction, to new non-random locations within nuclei upon a stimulus such as a signal to initiate differentiation, quiescence or senescence, or also the application of heat or an infection with a pathogen. It is now becoming increasingly obvious that chromosome and gene position can be altered in diseases such as cancer and other syndromes that are affected by changes to nuclear architecture such as the laminopathies. This repositioning seems to affect gene expression in these cells and may play a role in progression of the disease. We have some evidence in breast cancer cells and in the premature ageing disease Hutchinson-Gilford Progeria that an aberrant nuclear envelope may lead to genome repositioning and correction of these nuclear envelope defects can restore proper gene positioning and expression in both disease situations. Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply involved in regulating specific sets of genes. A deviation from normal spatial positioning of the genome for a particular cell type could lead to changes that affect the future health of the cell or even an individual.
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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 773)
The online version of the original chapter can be found at https://doi.org/10.1007/978-1-4899-8032-8_12
URI: https://bura.brunel.ac.uk/handle/2438/10082
DOI: https://doi.org/10.1007/978-1-4899-8032-8_28
ISBN: 978-1-4899-8031-1
978-1-4899-8032-8
ISSN: 0065-2598
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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