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Title: | Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy |
Authors: | Ryan, JM Crowley, VE Hensey, O McGahey, A Gormley, J |
Keywords: | risk factors;cerebral palsy;body mass index;metabolic syndrome X;rehabilitation;waist circumference |
Issue Date: | 14-Apr-2014 |
Publisher: | Elsevier |
Citation: | Ryan, J.M., Crowley, V.E., Hensey, O., McGahey, A. and Gormley, J. (2014) 'Waist Circumference Provides an Indication of Numerous Cardiometabolic Risk Factors in Adults With Cerebral Palsy', Archives of Physical Medicine and Rehabilitation, 95(8), pp. 1540-1546. doi: 10.1016/j.apmr.2014.03.029. |
Abstract: | Objective: To report the prevalence of cardiometabolic risk factors in a cohort of adults with cerebral palsy (CP) and to investigate the ability of anthropometric measures to predict these factors. Design: Cross-sectional study. Setting: Testing took place in a laboratory setting. Participants: Adults with CP (NZ55; mean age, 37.5 13.3y; Gross Motor Function Classification System levels, IeV) participated in this study. Interventions: Not applicable. Main Outcome Measures: Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and C-reactive protein levels were measured from a fasting venous blood sample. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC), waist-hip ratio, and waist-height ratio were also measured. The metabolic syndrome (MetS) was defined according to the 2009 Joint Interim Statement. Results: The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in nonambulatory adults. BMI was associated with HOMA-IR only (bZ.451; P<.01). WC was associated with HOMA-IR (bZ.480; P<.01), triglycerides (bZ.450; P<.01), and systolic blood pressure (bZ.352; P<.05). Receiver operating characteristic curve analysis revealed that WC provided the best indication of hypertensive blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors (area under the curve, .713e.763). Conclusions: A high prevalence of the MetS was observed in this relatively young sample of adults with CP. WC was a better indicator of a number of risk factors than was BMI and presents as a clinically useful method of screening for cardiometabolic risk among adults with CP. |
Description: | This article has been made available through the Brunel Open Access Publishing Fund. |
URI: | https://bura.brunel.ac.uk/handle/2438/10141 |
DOI: | https://doi.org/10.1016/j.apmr.2014.03.029 |
ISSN: | 0003-9993 |
Appears in Collections: | Biological Sciences Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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