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DC Field | Value | Language |
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dc.contributor.author | Wazir, U | - |
dc.contributor.author | Sharma, AK | - |
dc.contributor.author | Mokbel, K | - |
dc.contributor.author | Ahmed, MH | - |
dc.contributor.author | Bridger, JM | - |
dc.contributor.author | Harvey, A | - |
dc.contributor.author | Jiang, WG | - |
dc.date.accessioned | 2015-02-09T16:12:08Z | - |
dc.date.available | 2013 | - |
dc.date.available | 2015-02-09T16:12:08Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Cellular and Molecular Biology Letters, 18(4): 1 - 17, (December 2013) | en_US |
dc.identifier.issn | 1425-8153 | - |
dc.identifier.issn | 1689-1392 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/10164 | - |
dc.identifier.uri | http://www.degruyter.com/view/j/cmble.2013.18.issue-4/s11658-013-0109-9/s11658-013-0109-9.xml | - |
dc.description.abstract | Lamin A/C (LMNA), lamin B1 (LMNB1) and lamin B receptor (LBR) have key roles in nuclear structural integrity and chromosomal stability. In this study, we have studied the relationships between the mRNA expressions of A-type lamins, LMNB1 and LBR and the clinicopathological parameters in human breast cancer. Samples of breast cancer tissues (n = 115) and associated non-cancerous tissue (ANCT; n = 30) were assessed using reverse transcription and quantitative PCR. Transcript levels were correlated with clinicopathological data. Higher levels of A-type lamins and LMNB1 mRNA expression were seen in ANCT. Higher lamin A/C expression was associated with the early clinical stage (TNM1 vs. TNM3 - 13 vs. 0.21; p = 0.0515), with better clinical outcomes (disease-free survival vs. mortality - 11 vs. 1; p = 0.0326), and with better overall (p = 0.004) and disease-free survival (p = 0.062). The expression of LMNB1 declined with worsening clinical outcome (disease-free vs. mortalities - 0.0011 vs. 0.000; p = 0.0177). LBR mRNA expression was directly associated with tumor grade (grade 1 vs. grade 3-0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 vs. NPI3-0.00 vs. 0.00; p = 0.0551). To the best of our knowledge, this is the first study to suggest such a role for A-type lamins, lamin B1 and LBR in human breast cancer, identifying an important area for further research. © 2013 Versita Warsaw and Springer-Verlag Wien. | en_US |
dc.description.sponsorship | This study was funded by grants from the Breast Cancer Hope Foundation (London, UK) and the Gordon Memorial Trust Fund to MHA. | en_US |
dc.format.extent | 1 - 17 | - |
dc.format.extent | 1 - 17 | - |
dc.language.iso | en | en_US |
dc.publisher | Walter de Gruyter GmbH | en_US |
dc.subject | Lamin A/C | en_US |
dc.subject | Lamin B | en_US |
dc.subject | Lamin B receptor | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | qPCR | en_US |
dc.subject | Chromosomal instability | en_US |
dc.subject | Cell senescence | en_US |
dc.subject | Cell cycle | en_US |
dc.subject | DNA repair | en_US |
dc.subject | Ageing | en_US |
dc.title | The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.2478/s11658-013-0109-9 | - |
dc.relation.isPartOf | Cellular and Molecular Biology Letters | - |
dc.relation.isPartOf | Cellular and Molecular Biology Letters | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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