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DC Field | Value | Language |
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dc.contributor.author | Yadav, AK | - |
dc.contributor.author | Chaudhari, H | - |
dc.contributor.author | Warke, H | - |
dc.contributor.author | Shah, PK | - |
dc.contributor.author | Dodagatta-Marri, E | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Madan, T | - |
dc.coverage.spatial | United States | - |
dc.coverage.spatial | United States | - |
dc.date.accessioned | 2015-03-04T12:09:21Z | - |
dc.date.available | 2014 | - |
dc.date.available | 2015-03-04T12:09:21Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | PLoS One, 9(10): e108815, (October 2014) | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108815 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/10333 | - |
dc.description | © 2014 Yadav et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.description.abstract | Collectins, collagen-containing Ca2+ dependent C-type lectins and a class of secretory proteins including SP-A, SP-D and MBL, are integral to immunomodulation and innate immune defense. In the present study, we aimed to investigate their placental transcript synthesis, labor associated differential expression and localization at feto-maternal interface, and their functional implication in spontaneous labor. The study involved using feto-maternal interface (placental/decidual tissues) from two groups of healthy pregnant women at term (≥37 weeks of gestation), undergoing either elective C-section with no labor ('NLc' group, n = 5), or normal vaginal delivery with spontaneous labor ('SLv' group, n = 5). The immune function of SP-D, on term placental explants, was analyzed for cytokine profile using multiplexed cytokine array. SP-A, SP-D and MBL transcripts were observed in the term placenta. The 'SLv' group showed significant up-regulation of SP-D (p = 0.001), and down-regulation of SP-A (p = 0.005), transcripts and protein compared to the 'NLc' group. Significant increase in 43 kDa and 50 kDa SP-D forms in placental and decidual tissues was associated with the spontaneous labor (p<0.05). In addition, the MMP-9-cleaved form of SP-D (25 kDa) was significantly higher in the placentae of 'SLv' group compared to the 'NLc' group (p = 0.002). Labor associated cytokines IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α and MCP-1 showed significant increase (p<0.05) in a dose dependent manner in the placental explants treated with nSP-D and rhSP-D. In conclusion, the study emphasizes that SP-A and SP-D proteins associate with the spontaneous labor and SP-D plausibly contributes to the pro-inflammatory immune milieu of feto-maternal tissues. | en_US |
dc.description.sponsorship | Funding provided by BT/PR15227/BRB/10/906/2011) Department of Biotechnology (DBT), Government of India http://dbtindia.nic.in/index.asp (TM) and Indian Council of Medical Research (ICMR) Junior Research Fellowship (JRF)/Senior Research Fellowship (SRF), Government of India, www.icmr.nic.in (AKY). | en_US |
dc.format.extent | e108815 - ? | - |
dc.format.extent | e108815 - ? | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.subject | Human placenta | en_US |
dc.subject | Collectins | en_US |
dc.subject | Spontaneous labor | en_US |
dc.subject | Cytokines | en_US |
dc.title | Differential expression of collectins in human placenta and role in inflammation during spontaneous Labor. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0108815 | - |
dc.relation.isPartOf | PLoS One | - |
dc.relation.isPartOf | PLoS One | - |
pubs.issue | 10 | - |
pubs.issue | 10 | - |
pubs.volume | 9 | - |
pubs.volume | 9 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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