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DC Field | Value | Language |
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dc.contributor.author | Pires, IM | - |
dc.contributor.author | Blokland, NJG | - |
dc.contributor.author | Broos, AWT | - |
dc.contributor.author | Poujade, F-A | - |
dc.contributor.author | Senra, JM | - |
dc.contributor.author | Eccles, SA | - |
dc.contributor.author | Span, PN | - |
dc.contributor.author | Harvey, AJ | - |
dc.contributor.author | Hammond, EM | - |
dc.date.accessioned | 2015-03-16T11:25:52Z | - |
dc.date.available | 2014-10-01 | - |
dc.date.available | 2015-03-16T11:25:52Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Pires, I.M., Blokland, N.J.G., Broos, A.W.T., Poujade, F.-A. Senra, J.M., Eccles, S.A., Span, P.N., Harvey, A.J. and Hammond, EM. (2014) 'HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion', Cancer Biology and Therapy, 15 (10), pp. 1350 - 1357. doi:10.4161/cbt.29822. | en_US |
dc.identifier.issn | 1538-4047 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/10410 | - |
dc.description | This article has been made available through the Brunel Open Access Publishing Fund. | - |
dc.description.abstract | PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease. | en_US |
dc.description.sponsorship | A Breast Cancer Campaign pilot grant awarded to E.M.H. supported this study. I.M.P. is supported by University of Hull HEFCE funding, and Royal Society and Breast Cancer Campaign pilot grants. S.A.E. is supported by ICR HEFCE funding and Cancer Research UK program grant C309/A11566. A.H. is supported by Brunel University HEFCE funding. E.M.H. is supported by a Cancer Research UK grant. | - |
dc.format.extent | 1350 - 1357 | - |
dc.format.extent | 1350 - 1357 | - |
dc.format.extent | 1350 - 1357 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Landes Bioscience | en_US |
dc.subject | Brk | en_US |
dc.subject | hypoxia | en_US |
dc.subject | invasion | en_US |
dc.subject | metastasis | en_US |
dc.subject | migration | en_US |
dc.subject | PTK6 | en_US |
dc.subject | ubiquitylation | en_US |
dc.title | HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.4161/cbt.29822 | - |
dc.relation.isPartOf | Cancer Biology and Therapy | - |
dc.relation.isPartOf | Cancer Biology and Therapy | - |
dc.relation.isPartOf | Cancer Biology and Therapy | - |
pubs.issue | 10 | - |
pubs.issue | 10 | - |
pubs.issue | 10 | - |
pubs.volume | 15 | - |
pubs.volume | 15 | - |
pubs.volume | 15 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
dc.identifier.eissn | 1555-8576 | - |
Appears in Collections: | Brunel OA Publishing Fund Dept of Life Sciences Research Papers |
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FullText.pdf | 1.37 MB | Adobe PDF | View/Open |
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