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Title: Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.
Authors: Tolmachov, O
Ma, YL
Themis, M
Patel, P
Spohr, H
Macleod, KT
Ullrich, ND
Kienast, Y
Coutelle, C
Peters, NS
Keywords: Skeletal myoblasts;Retroviral vector;Connexin 43;Electromyography;Cardiac myocytes;Vitro
Issue Date: 2006
Publisher: BioMed Central
Citation: BMC Cardiovascular Disorders, 6: 25, (2006)
Abstract: Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy. The functionality of skeletal muscle cells in the heart milieu is, however, limited because of their inability to integrate electrically and mechanically into the myocardium. Therefore, in pursuit of improved cardiac integration of skeletal muscle grafts we sought to modify primary skeletal myoblasts by overexpression of the main gap-junctional protein connexin 43 and to study electrical coupling of connexin 43 overexpressing myoblasts to cardiac myocytes in vitro.
Description: © 2006 Tolmachov et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN: 1471-2261
Appears in Collections:Dept of Life Sciences Research Papers

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