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DC Field | Value | Language |
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dc.contributor.author | Chiesa, ST | - |
dc.contributor.author | Trangmar, SJ | - |
dc.contributor.author | Kalsi, KK | - |
dc.contributor.author | Rakobowchuk, M | - |
dc.contributor.author | Banker, DS | - |
dc.contributor.author | Lotlikar, MD | - |
dc.contributor.author | Ali, L | - |
dc.contributor.author | González-Alonso, J | - |
dc.date.accessioned | 2015-11-18T16:24:15Z | - |
dc.date.available | 2015-05-01 | - |
dc.date.available | 2015-11-18T16:24:15Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | American Journal of Physiology - Heart and Circulatory Physiology , 309(2): H369-H380, (15 July 2015) | en_US |
dc.identifier.issn | 1522-1539 | - |
dc.identifier.uri | http://ajpheart.physiology.org/content/309/2/H369 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/11619 | - |
dc.description.abstract | Limb tissue and systemic blood flow increases with heat stress, but the underlying mechanisms remain poorly understood. Here, we tested the hypothesis that heat stress-induced increases in limb tissue perfusion are primarily mediated by local temperature-sensitive mechanisms. Leg and systemic temperatures and hemodynamics were measured at rest and during incremental single-legged knee extensor exercise in 15 males exposed to 1 h of either systemic passive heat-stress with simultaneous cooling of a single leg (n=8) or isolated leg heating or cooling (n=7). Systemic heat-stress increased core, skin and heated leg blood (Tb) temperatures, cardiac output and heated leg blood flow (LBF, 0.6 ± 0.1 l.min(-1); P<0.05). In the cooled leg, however, LBF remained unchanged throughout (P>0.05). Increased heated leg deep tissue BF was closely related to Tb (R(2) = 0.50; P<0.01), which is partly attributed to increases in tissue V̇O2 (R(2) = 0.55; P<0.01) accompanying elevations in total leg glucose uptake (P<0.05). During isolated limb heating and cooling, LBFs were equivalent to those found during systemic heat-stress (P>0.05), despite unchanged systemic temperatures and hemodynamics. During incremental exercise, heated LBF was consistently maintained ~ 0.6 l.min(-1) higher than that in the cooled leg (P<0.01), with LBF and vascular conductance in both legs showing a strong correlation with their respective local Tb (R(2) = 0.85 and 0.95, P<0.05). We conclude that local temperature-sensitive mechanisms are important mediators in limb tissue perfusion regulation both at rest and during small-muscle mass exercise in hyperthermic humans. | en_US |
dc.description.sponsorship | The invasive study was partially funded by Gatorade Sports Science Institute, PepsiCo. | en_US |
dc.format.extent | ajpheart.00078.2015 - ajpheart.00078.2015 | - |
dc.language | ENG | - |
dc.language.iso | en | en_US |
dc.publisher | American Physiological Society | en_US |
dc.subject | Exercise | en_US |
dc.subject | Heat stress | en_US |
dc.subject | Leg blood flow | en_US |
dc.title | Local temperature-sensitive mechanisms are important mediators of limb tissue hyperemia in the heat-stressed human at rest and during small muscle mass exercise. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1152/ajpheart.00078.2015 | - |
dc.relation.isPartOf | Am J Physiol Heart Circ Physiol | - |
pubs.notes | Archiving is not formally supported by this publisher. "The author’s published article (in whole or in part) may not be posted to an institutional website, neither at the institutional nor departmental level. This exclusion includes, but is not limited to, library websites and national government websites. Instead, a link to the article on the APS journal website should be used." | - |
pubs.notes | Archiving is not formally supported by this publisher. "The author’s published article (in whole or in part) may not be posted to an institutional website, neither at the institutional nor departmental level. This exclusion includes, but is not limited to, library websites and national government websites. Instead, a link to the article on the APS journal website should be used." | - |
pubs.publication-status | Published | - |
pubs.publication-status | Published | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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