Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/11683
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Deacon, RMJ | - |
dc.contributor.author | Altimiras, FJ | - |
dc.contributor.author | Bazán-León, EA | - |
dc.contributor.author | Pyarasani, RD | - |
dc.contributor.author | Nachtigall, FM | - |
dc.contributor.author | Santos, LS | - |
dc.contributor.author | Tsolaki, AG | - |
dc.contributor.author | Pednekar, L | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Biekofsky, RR | - |
dc.contributor.author | Vásquez, RA | - |
dc.contributor.author | Cogram, P | - |
dc.date.accessioned | 2015-12-02T13:47:53Z | - |
dc.date.available | 2015-01-01 | - |
dc.date.available | 2015-12-02T13:47:53Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Current Alzheimer Research,12 (4): pp. 314 - 322, (2015) | en_US |
dc.identifier.issn | 1567-2050 | - |
dc.identifier.issn | 1875-5828 | - |
dc.identifier.uri | http://www.eurekaselect.com/129747/article | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/11683 | - |
dc.description.abstract | Alzheimer’s disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs of AD, including amyloid-β (Aβ) and tau deposits, as well as a decline in cognition with age. Firstly, the present work introduces a novel behavioral assessment for O. degus - the burrowing test - which appears to be a useful tool for detecting neurodegeneration in the O. degus model for AD. Such characterization has potentially wide-ranging implications, because many of these changes in species-typical behaviors are reminiscent of the impairments in activities of daily living (ADL), so characteristic of human AD. Furthermore, the present work characterizes the ADlike neuropathology in O. degus from a gene expression point of view, revealing a number of previously unreported AD biomarkers, which are found in human AD: amyloid precursor protein (APP), apolipoprotein E (ApoE), oxidative stressrelated genes from the NFE2L2 and PPAR pathway, as well as pro-inflammatory cytokines and complement proteins, in agreement with the known link between neurodegeneration and neuroinflammation. In summary, the present results confirm a natural neuropathology in O. degus with similar characteristics to AD at behavioral, cellular and molecular levels. These characteristics put O. degus in a singular position as a natural rodent model for research into AD pathogenesis and therapeutics against AD. | en_US |
dc.description.sponsorship | Research was conducted under permit No. 5193 issued by the Servicio Agrícola y Ganadero, Chile, with the supervision of the Ethics Committee of the Faculty of Sciences, Universidad de Chile. | en_US |
dc.format.extent | 314 - 322 | - |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science | en_US |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | Beta-amyloid | en_US |
dc.subject | Burrowing | en_US |
dc.subject | Complement | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Octodon degus | en_US |
dc.title | Natural AD-like neuropathology in Octodon degus: Impaired burrowing and neuroinflammation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.2174/1567205012666150324181652 | - |
dc.relation.isPartOf | Current Alzheimer Research | - |
pubs.issue | 4 | - |
pubs.publication-status | Published | - |
pubs.publication-status | Published | - |
pubs.volume | 12 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 761.61 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.