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DC Field | Value | Language |
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dc.contributor.author | Simpson, AJ | - |
dc.contributor.author | Bood, JR | - |
dc.contributor.author | Anderson, SD | - |
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Dahlén, B | - |
dc.contributor.author | Dahlén, S-E | - |
dc.contributor.author | Kippelen, P | - |
dc.date.accessioned | 2016-02-17T15:43:06Z | - |
dc.date.available | 2016-02-17T15:43:06Z | - |
dc.date.issued | 2016-05-01 | - |
dc.identifier.citation | Journal of Applied Physiology, 120(9): pp. 1011 - 1017, (2016) | en_US |
dc.identifier.issn | 8750-7587 | - |
dc.identifier.uri | https://www.physiology.org/doi/full/10.1152/japplphysiol.00700.2015 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/12117 | - |
dc.description.abstract | Release of broncho-active mediators from mast cells during exercise hyperpnoea is a key factor in the pathophysiology of exercise-induced bronchoconstriction (EIB). Our aim was to investigate the effect of a standard, single dose of an inhaled β2-adrenoceptor agonist on mast cell activation in response to dry air hyperpnoea in athletes with EIB. Twenty-seven athletes with EIB completed a randomised, double blind, placebo-controlled, crossover study. Terbutaline (0.5 mg) or placebo was inhaled15 min prior to 8 min of eucapnic voluntary hyperpnoea (EVH) with dry air. Pre- and post-bronchial challenge, urine samples were analysed by enzyme immunoassay for 11β-prostaglandin(PG)F2α. The maximum fall in forced expiratory volume in 1 sec(FEV1) of 14 (12-20)% (median and interquartile range) following placebo was attenuated to 7 (5-9)% with the administration of terbutaline (P<0.001). EVH caused a significant increase in 11β-PGF2α from (27-57) ng·mmol creatinine-1 at baseline to (43-72) ng·mmol creatinine-1 at its peak post-EVH following placebo (P=0.002). The rise in 11β-PGF2α was inhibited with administration of terbutaline: 39 (28-44) ng·mmol creatinine-1 at baseline vs. 40 (33-58) ng·mmol creatinine-1 at its peak post-EVH (P=0.118). These data provide novel in vivo evidence of mast cell stabilisation following inhalation of a standard dose of terbutaline prior to bronchial provocation with EVH in athletes with EIB. | en_US |
dc.format.extent | jap.00700.2015 - jap.00700.2015 | - |
dc.language.iso | en | en_US |
dc.publisher | American Physiological Society | en_US |
dc.rights | Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/deed.en_US | - |
dc.subject | inhaled β2-agonist | en_US |
dc.subject | exercise-induced bronchoconstriction | en_US |
dc.subject | eucapnic voluntary hyperpnoea | en_US |
dc.subject | prostaglandin D2 | en_US |
dc.title | A standard, single dose of inhaled terbutaline attenuates hyperpnoea-induced bronchoconstriction and mast cell activation in athletes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1152/japplphysiol.00700.2015 | - |
dc.relation.isPartOf | Journal of Applied Physiology | - |
pubs.publication-status | Published online | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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