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DC Field | Value | Language |
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dc.contributor.author | Kouser, L | - |
dc.contributor.author | Madhukaran, SP | - |
dc.contributor.author | Shastri, A | - |
dc.contributor.author | Saraon, A | - |
dc.contributor.author | Ferluga, J | - |
dc.contributor.author | Al-Mozaini, M | - |
dc.contributor.author | Kishore, U | - |
dc.date.accessioned | 2016-07-19T11:09:44Z | - |
dc.date.available | 2015-01-01 | - |
dc.date.available | 2016-07-19T11:09:44Z | - |
dc.date.issued | 2015-06-29 | - |
dc.identifier.citation | Kouser, L., Madhukaran, S.P., Shastri, A., Saraon, A., Ferluga, J., Al-Mozaini, M. and Kishore, U. (2015) 'Emerging and novel functions of complement protein C1q', Frontiers in Immunology, 6, 317, pp. 1-19. doi: 10.3389/fimmu.2015.00317. | - |
dc.identifier.other | 317 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/12971 | - |
dc.description.abstract | Copyright: © 2015 Kouser, Madhukaran, Shastri, Saraon, Ferluga, Al-Mozaini and Kishore. Complement protein C1q, the recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells including dendritic cells and microglia. C1q involvement in the clearance of apoptotic cells and subsequent B cell tolerance is more established now. Recent evidence appears to suggest that C1q plays an important role in pregnancy where its deficiency and dysregulation can have adverse effects, leading to preeclampsia, missed abortion, miscarriage or spontaneous loss, and various infections. C1q is also produced locally in the central nervous system, and has a protective role against pathogens and possible inflammatory functions while interacting with aggregated proteins leading to neurodegenerative diseases. C1q role in synaptic pruning, and thus CNS development, its anti-cancer effects as an immune surveillance molecule, and possibly in aging are currently areas of extensive research. | en_US |
dc.format.extent | 1 - 19 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | Copyright: © 2015 Kouser, Madhukaran, Shastri, Saraon, Ferluga, Al-Mozaini and Kishore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.rights | Copyright: © 2015 Kouser, Madhukaran, Shastri, Saraon, Ferluga, Al-Mozaini and Kishore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Complement | en_US |
dc.subject | C1q | en_US |
dc.subject | apoptosis | en_US |
dc.subject | neurogenesis | en_US |
dc.subject | pregnancy | en_US |
dc.subject | cancer | en_US |
dc.title | Emerging and novel functions of complement protein C1q | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2015.00317 | - |
dc.relation.isPartOf | Frontiers in Immunology | - |
pubs.issue | JUN | - |
pubs.publication-status | Published | - |
pubs.volume | 6 | - |
dc.identifier.eissn | 1664-3224 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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