Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/13432
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DC Field | Value | Language |
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dc.contributor.author | Kanoni, S | - |
dc.contributor.author | Masca, NGD | - |
dc.contributor.author | Stirrups, KE | - |
dc.contributor.author | Varga, TV | - |
dc.contributor.author | Warren, HR | - |
dc.contributor.author | Scott, RA | - |
dc.contributor.author | Southam, L | - |
dc.contributor.author | Zhang, W | - |
dc.contributor.author | Yaghootkar, H | - |
dc.contributor.author | Müller-Nurasyid, M | - |
dc.contributor.author | Couto Alves, A | - |
dc.contributor.author | Strawbridge, RJ | - |
dc.contributor.author | Lataniotis, L | - |
dc.contributor.author | Hashim, NAN | - |
dc.contributor.author | Besse, C | - |
dc.contributor.author | Boland, A | - |
dc.contributor.author | Braund, PS | - |
dc.contributor.author | Connell, JM | - |
dc.contributor.author | Dominiczak, A | - |
dc.contributor.author | Farmaki, A-E | - |
dc.contributor.author | Franks, S | - |
dc.contributor.author | Grallert, H | - |
dc.contributor.author | Jansson, J-H | - |
dc.contributor.author | Karaleftheri, M | - |
dc.contributor.author | Keinänen-Kiukaanniemi, S | - |
dc.contributor.author | Matchan, A | - |
dc.contributor.author | Pasko, D | - |
dc.contributor.author | Peters, A | - |
dc.contributor.author | Poulter, N | - |
dc.contributor.author | Rayner, NW | - |
dc.contributor.author | Renström, F | - |
dc.contributor.author | Rolandsson, O | - |
dc.contributor.author | Sabater-Lleal, M | - |
dc.contributor.author | Sennblad, B | - |
dc.contributor.author | Sever, P | - |
dc.contributor.author | Shields, D | - |
dc.contributor.author | Silveira, A | - |
dc.contributor.author | Stanton, AV | - |
dc.contributor.author | Strauch, K | - |
dc.contributor.author | Tomaszewski, M | - |
dc.contributor.author | Tsafantakis, E | - |
dc.contributor.author | Waldenberger, M | - |
dc.contributor.author | Blakemore, AIF | - |
dc.contributor.author | Dedoussis, G | - |
dc.contributor.author | Escher, SA | - |
dc.contributor.author | Kooner, JS | - |
dc.contributor.author | McCarthy, MI | - |
dc.contributor.author | Palmer, CNA | - |
dc.contributor.author | Hamsten, A | - |
dc.contributor.author | Caulfield, MJ | - |
dc.contributor.author | Frayling, TM | - |
dc.contributor.author | Tobin, MD | - |
dc.contributor.author | Jarvelin, M-R | - |
dc.contributor.author | Zeggini, E | - |
dc.contributor.author | Gieger, C | - |
dc.contributor.author | Chambers, JC | - |
dc.contributor.author | Wareham, NJ | - |
dc.contributor.author | Munroe, PB | - |
dc.contributor.author | Franks, PW | - |
dc.contributor.author | Samani, NJ | - |
dc.contributor.author | Deloukas, P | - |
dc.date.accessioned | 2016-10-31T16:16:53Z | - |
dc.date.available | 2016-07-27 | - |
dc.date.available | 2016-10-31T16:16:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Human Molecular Genetics, 2016, pp. ddw227 - ddw227 | en_US |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/13432 | - |
dc.description.abstract | It has been hypothesized that low frequency (1–5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27 312 individuals with a comprehensive set of low frequency coding variants (ExomeChip), combined with conditional analysis in the known lipid loci. No new locus reached genome-wide significance. However, we found a new lead variant in 26 known lipid association regions of which 16 were >1000-fold more significant than the previous sentinel variant and not in close LD (six had MAF <5%). Furthermore, conditional analysis revealed multiple independent signals (ranging from 1 to 5) in a third of the 98 lipid loci tested, including rare variants. Addition of our novel associations resulted in between 1.5- and 2.5-fold increase in the proportion of heritability explained for the different lipid traits. Our findings suggest that rare coding variants contribute to the genetic architecture of lipid traits. | en_US |
dc.format.extent | ddw227 - ddw227 | - |
dc.language.iso | en | en_US |
dc.title | Analysis with the exome array identifies multiple new independent variants in lipid loci | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1093/hmg/ddw227 | - |
dc.relation.isPartOf | Human Molecular Genetics | - |
pubs.publication-status | Published online | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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File | Description | Size | Format | |
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FullText.pdf | 235.33 kB | Adobe PDF | View/Open |
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