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DC Field | Value | Language |
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dc.contributor.author | Simpson, AJ | - |
dc.contributor.author | Romer, LM | - |
dc.contributor.author | Kippelen, P | - |
dc.date.accessioned | 2017-03-08T16:16:33Z | - |
dc.date.available | 2017-03-08T16:16:33Z | - |
dc.date.issued | 2017-05-01 | - |
dc.identifier.citation | Simpson, A.J., Romer, L.M. and Kippelen, P. (2017) 'Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma', Journal of applied physiology, 122(5), pp. 1329-1335. doi: 10.1152/japplphysiol.01114.2016. | en_US |
dc.identifier.issn | 8750-7587 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/14208 | - |
dc.description.abstract | Background: Local airway water loss is the main physiological trigger for exercise induced bronchoconstriction (EIB). Aim: To investigate the effects of whole-body water loss on airway responsiveness and pulmonary function in athletes with mild asthma and/or EIB. Methods: Ten recreational athletes with a doctor diagnosis of mild asthma and/or EIB completed a randomized, cross-over study. Pulmonary function tests (spirometry, whole body plethysmography and diffusing capacity for carbon monoxide [DLCO]) were conducted before and after three conditions: i) 2 h exercise in the heat with no fluid intake (dehydration); ii) 2 h exercise with ad libitum fluid intake (control); and iii) time-matched rest period (rest). Airway responsiveness was assessed 2 h post-exercise/rest via eucapnic voluntary hyperpnea (EVH) to dry air. Results: Exercise in the heat with no fluid intake induced a state of mild dehydration, with a mean body mass loss of 2.3±0.8% (SD). After EVH, airway narrowing was not different between conditions: median (interquartile range) maximum fall in forced expiratory volume in 1 sec was 13 (7–15)%, 11 (9–24)% and 12 (7–20)% in the dehydration, control and rest conditions, respectively. Dehydration caused a significant reduction in forced vital capacity (300±190 ml, P=0.001) and concomitant increases in residual volume (260±180 ml, P=0.001) and functional residual capacity (260±250 ml, P=0.011), with no change in DLCO. Conclusion: Mild exercise induced dehydration does not exaggerate airway responsiveness to dry air in athletes with mild asthma/EIB, but may affect small airway function. | en_US |
dc.description.sponsorship | This study was supported by the European Hydration Institute Student Research Grant Scheme. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Physiological Society | en_US |
dc.rights | Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/deed.en_US | - |
dc.subject | airway hyper-responsiveness | en_US |
dc.subject | eucapnic voluntary hyperpnea | en_US |
dc.subject | exercise-induced bronchoconstriction | en_US |
dc.subject | exercise-induced asthma | en_US |
dc.subject | whole-body dehydration | en_US |
dc.title | Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1152/japplphysiol.01114.2016 | - |
dc.identifier.doi | 1522-1601 | - |
dc.relation.isPartOf | Journal of Applied Physiology | - |
pubs.publication-status | Published | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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