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DC Field | Value | Language |
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dc.contributor.author | Bradfield, JP | - |
dc.contributor.author | Taal, HR | - |
dc.contributor.author | Timpson, NJ | - |
dc.contributor.author | Scherag, A | - |
dc.contributor.author | Lecoeur, C | - |
dc.contributor.author | Warrington, NM | - |
dc.contributor.author | Hypponen, E | - |
dc.contributor.author | Holst, C | - |
dc.contributor.author | Valcarcel, B | - |
dc.contributor.author | Thiering, E | - |
dc.contributor.author | Salem, RM | - |
dc.contributor.author | Schumacher, FR | - |
dc.contributor.author | Cousminer, DL | - |
dc.contributor.author | Sleiman, PMA | - |
dc.contributor.author | Zhao, J | - |
dc.contributor.author | Berkowitz, RI | - |
dc.contributor.author | Vimaleswaran, KS | - |
dc.contributor.author | Jarick, I | - |
dc.contributor.author | Pennell, CE | - |
dc.contributor.author | Evans, DM | - |
dc.contributor.author | St Pourcain, B | - |
dc.contributor.author | Berry, DJ | - |
dc.contributor.author | Mook-Kanamori, DO | - |
dc.contributor.author | Hofman, A | - |
dc.contributor.author | Rivadeneira, F | - |
dc.contributor.author | Uitterlinden, AG | - |
dc.contributor.author | van Duijn, CM | - |
dc.contributor.author | van der Valk, RJP | - |
dc.contributor.author | de Jongste, JC | - |
dc.contributor.author | Postma, DS | - |
dc.contributor.author | Boomsma, DI | - |
dc.contributor.author | Gauderman, WJ | - |
dc.contributor.author | Hassanein, MT | - |
dc.contributor.author | Lindgren, CM | - |
dc.contributor.author | Magi, R | - |
dc.contributor.author | Boreham, CAG | - |
dc.contributor.author | Neville, CE | - |
dc.contributor.author | Moreno, LA | - |
dc.contributor.author | Elliott, P | - |
dc.contributor.author | Pouta, A | - |
dc.contributor.author | Hartikainen, A-L | - |
dc.contributor.author | Li, M | - |
dc.contributor.author | Raitakari, O | - |
dc.contributor.author | Lehtimaki, T | - |
dc.contributor.author | Eriksson, JG | - |
dc.contributor.author | Palotie, A | - |
dc.contributor.author | Dallongeville, J | - |
dc.contributor.author | Das, S | - |
dc.contributor.author | Deloukas, P | - |
dc.contributor.author | McMahon, G | - |
dc.contributor.author | Ring, SM | - |
dc.contributor.author | Kemp, JP | - |
dc.contributor.author | Buxton, JL | - |
dc.contributor.author | Blakemore, AIF | - |
dc.contributor.author | Bustamante, M | - |
dc.contributor.author | Guxens, M | - |
dc.contributor.author | Hirschhorn, JN | - |
dc.contributor.author | Gillman, MW | - |
dc.contributor.author | Kreiner-Moller, E | - |
dc.contributor.author | Bisgaard, H | - |
dc.contributor.author | Gilliland, FD | - |
dc.contributor.author | Heinrich, J | - |
dc.contributor.author | Wheeler, E | - |
dc.contributor.author | Barroso, I | - |
dc.contributor.author | O'Rahilly, S | - |
dc.contributor.author | Meirhaeghe, A | - |
dc.contributor.author | Sorensen, TIA | - |
dc.contributor.author | Power, C | - |
dc.contributor.author | Palmer, LJ | - |
dc.contributor.author | Hinney, A | - |
dc.contributor.author | Widen, E | - |
dc.contributor.author | Farooqi, IS | - |
dc.contributor.author | McCarthy, MI | - |
dc.contributor.author | Froguel, P | - |
dc.contributor.author | Meyre, D | - |
dc.contributor.author | Hebebrand, J | - |
dc.contributor.author | Jarvelin, M-R | - |
dc.contributor.author | Jaddoe, VWV | - |
dc.contributor.author | Smith, GD | - |
dc.contributor.author | Hakonarson, H | - |
dc.contributor.author | Grant, SFA | - |
dc.date.accessioned | 2017-06-01T11:08:51Z | - |
dc.date.available | 2012-05-01 | - |
dc.date.available | 2017-06-01T11:08:51Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Nature Genetics, 44(5): pp. 526 - 531, (2012) | en_US |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/14649 | - |
dc.description.abstract | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1. | en_US |
dc.format.extent | 526 - + (7) | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | Body-mass index | en_US |
dc.subject | Helicobacter-pylori | en_US |
dc.subject | Disease genetics | en_US |
dc.subject | Genome-wide association studies | en_US |
dc.subject | Obesity | en_US |
dc.title | A genome-wide association meta-analysis identifies new childhood obesity loci | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1038/ng.2247 | - |
dc.relation.isPartOf | NATURE GENETICS | - |
pubs.issue | 5 | - |
pubs.publication-status | Published | - |
pubs.volume | 44 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 247.15 kB | Adobe PDF | View/Open |
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