Title: | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index |
Authors: | Speliotes, EK Willer, CJ Berndt, SI Monda, KL Thorleifsson, G Jackson, AU Allen, HL Lindgren, CM Luan, J Maegi, R Randall, JC Busonero, F Campbell, H Cappuccio, FP Cavalcanti-Proenca, C Chen, Y-DI Chen, C-M Chines, PS Clarke, R Coin, L Connell, J Vedantam, S Day, INM den Heijer, M Duan, J Ebrahim, S Elliott, P Elosua, R Eiriksdottir, G Erdos, MR Eriksson, JG Facheris, MF Winkler, TW Felix, SB Fischer-Posovszky, P Folsom, AR Friedrich, N Freimer, NB Fu, M Gaget, S Gejman, PV Geus, EJC Gieger, C Qi, L Gjesing, AP Goel, A Goyette, P Grallert, H Graessler, J Greenawalt, DM Groves, CJ Gudnason, V Guiducci, C Hartikainen, A-L Workalemahu, T Hassanali, N Hall, AS Havulinna, AS Hayward, C Heath, AC Hengstenberg, C Hicks, AA Hinney, A Hofman, A Homuth, G Heid, IM Hui, J Igl, W Iribarren, C Isomaa, B Jacobs, KB Jarick, I Jewell, E John, U Jorgensen, T Jousilahti, P Steinthorsdottir, V Jula, A Kaakinen, M Kajantie, E Kaplan, LM Kathiresan, S Kettunen, J Kinnunen, L Knowles, JW Kolcic, I Koenig, IR Stringham, HM Koskinen, S Kovacs, P Kuusisto, J Kraft, P Kvaloy, K Laitinen, J Lantieri, O Lanzani, C Launer, LJ Lecoeur, C Weedon, MN Lehtimaeki, T Lettre, G Liu, J Lokki, M-L Lorentzon, M Luben, RN Ludwig, B Manunta, P Marek, D Marre, M Wheeler, E Martin, NG McArdle, WL McCarthy, A McKnight, B Meitinger, T Melander, O Meyre, D Midthjell, K Montgomery, GW Morken, MA Wood, AR Morris, AP Mulic, R Ngwa, JS Nelis, M Neville, MJ Nyholt, DR O'Donnell, CJ O'Rahilly, S Ong, KK Oostra, B Ferreira, T Pare, G Parker, AN Perola, M Pichler, I Pietilaeinen, KH Platou, CGP Polasek, O Pouta, A Rafelt, S Raitakari, O Weyant, RJ Rayner, NW Ridderstrale, M Rief, W Ruokonen, A Robertson, NR Rzehak, P Salomaa, V Sanders, AR Sandhu, MS Sanna, S Segre, AV Saramies, J Savolainen, MJ Scherag, S Schipf, S Schreiber, S Schunkert, H Silander, K Sinisalo, J Siscovick, DS Smit, JH Estrada, K Soranzo, N Sovio, U Stephens, J Surakka, I Swift, AJ Tammesoo, M-L Tardif, J-C Teder-Laving, M Teslovich, TM Thompson, JR Liang, L Thomson, B Toenjes, A Tuomi, T van Meurs, JBJ van Ommen, G-J Vatin, V Viikari, J Visvikis-Siest, S Vitart, V Vogel, CIG Nemesh, J Voight, BF Waite, LL Wallaschofski, H Walters, GB Widen, E Wiegand, S Wild, SH Willemsen, G Witte, DR Witteman, JC Park, J-H Xu, J Zhang, Q Zgaga, L Ziegler, A Zitting, P Beilby, JP Farooqi, IS Hebebrand, J Huikuri, HV James, AL Gustafsson, S Kaehoenen, M Levinson, DF Macciardi, F Nieminen, MS Ohlsson, C Palmer, LJ Ridker, PM Stumvoll, M Beckmann, JS Boeing, H Kilpelaenen, TO Boerwinkle, E Boomsma, DI Caulfield, MJ Chanock, SJ Collins, FS Cupples, LA Smith, GD Erdmann, J Froguel, P Greonberg, H Yang, J Gyllensten, U Hall, P Hansen, T Harris, TB Hattersley, AT Hayes, RB Heinrich, J Hu, FB Hveem, K Illig, T Bouatia-Naji, N Jarvelin, M-R Kaprio, J Karpe, F Khaw, K-T Kiemeney, LA Krude, H Laakso, M Lawlor, DA Metspalu, A Munroe, PB Esko, T Ouwehand, WH Pedersen, O Penninx, BW Peters, A Pramstaller, PP Quertermous, T Reinehr, T Rissanen, A Rudan, I Samani, NJ Feitosa, MF Schwarz, PEH Shuldiner, AR Spector, TD Tuomilehto, J Uda, M Uitterlinden, A Valle, TT Wabitsch, M Waeber, G Wareham, NJ Kutalik, Z Watkins, H Wilson, JF Wright, AF Zillikens, MC Chatterjee, N McCarroll, SA Purcell, S Schadt, EE Visscher, PM Assimes, TL Mangino, M Borecki, IB Deloukas, P Fox, CS Groop, LC Haritunians, T Hunter, DJ Kaplan, RC Mohlke, KL O'Connell, JR Peltonen, L Raychaudhuri, S Schlessinger, D Strachan, DP van Duijn, CM Wichmann, H-E Frayling, TM Thorsteinsdottir, U Abecasis, GR Barroso, I Boehnke, M Stefansson, K Scherag, A North, KE McCarthy, MI Hirschhorn, JN Ingelsson, E Loos, RJF Smith, AV Welch, R Zhao, JH Aben, KK Absher, DM Amin, N Dixon, AL Fisher, E Glazer, NL Goddard, ME Heard-Costa, NL Hoesel, V Hottenga, J-J Johansson, A Johnson, T Ketkar, S Lamina, C Li, S Moffatt, MF Myers, RH Narisu, N Perry, JRB Peters, MJ Preuss, M Ripatti, S Rivadeneira, F Sandholt, C Scott, LJ Timpson, NJ Tyrer, JP van Wingerden, S Watanabe, RM White, CC Wiklund, F Barlassina, C Chasman, DI Cooper, MN Jansson, J-O Lawrence, RW Pellikka, N Prokopenko, I Shi, J Thiering, E Alavere, H Alibrandi, MTS Almgren, P Arnold, AM Aspelund, T Atwood, LD Balkau, B Balmforth, AJ Bennett, AJ Ben-Shlomo, Y Bergman, RN Bergmann, S Biebermann, H Blakemore, AIF Boes, T Bonnycastle, LL Bornstein, SR Brown, MJ Buchanan, TA |
Keywords: | Science & Technology;Life Sciences & Biomedicine;Genetics & Heredity;GENETICS & HEREDITY;GENOME-WIDE ASSOCIATION;GASTRIC-INHIBITORY POLYPEPTIDE;MELANOCORTIN-4 RECEPTOR GENE;GLUCOSE-HOMEOSTASIS;COMMON VARIANTS;ADULT OBESITY;EARLY-ONSET;FTO GENE;FAT MASS;RISK |
Issue Date: | 2010 |
Publisher: | Nature Publishing Group |
Citation: | NATURE GENETICS, 42 (11): pp. 937 - U53 (14), (2010) |
Abstract: | Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity-susceptibility loci and identified 18 new loci associated with BMI (P<5×10−8), one of which includes a copy number variant near GPRC5B. Some loci (MC4R, POMC, SH2B1, BDNF) map near key hypothalamic regulators of energy balance, and one is near GIPR, an incretin receptor. Furthermore, genes in other newly-associated loci may provide novel insights into human body weight regulation. |
URI: | http://bura.brunel.ac.uk/handle/2438/14660 |
DOI: | http://dx.doi.org/10.1038/ng.686 |
ISSN: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 1061-4036 |
Appears in Collections: | Dept of Life Sciences Research Papers
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